Reaction Details Report a problem with these data
Target
Fructose-1,6-bisphosphatase 1
Ligand
BDBM50095261
Substrate
n/a
Meas. Tech.
ChEBML_86713
IC50
1600±n/a nM
Citation
 Wright, SW; Hageman, DL; McClure, LD; Carlo, AA; Treadway, JL; Mathiowetz, AM; Withka, JM; Bauer, PH Allosteric inhibition of fructose-1,6-bisphosphatase by anilinoquinazolines. Bioorg Med Chem Lett 11:17-21 (2001) [PubMed]  Article 
Target
Name:
Fructose-1,6-bisphosphatase 1
Synonyms:
D-fructose-1,6-bisphosphate 1-phosphohydrolase 1 | F16P1_HUMAN | FBP | FBP1 | FBPase 1 | Fructose-1,6-bisphosphatase | Fructose-1,6-bisphosphatase 1 | Fructose-1,6-bisphosphatase 1 (FBPase)
Type:
Protein
Mol. Mass.:
36843.58
Organism:
Human
Description:
Liver FBPase (P09467)
Residue:
338
Sequence:
MADQAPFDTDVNTLTRFVMEEGRKARGTGELTQLLNSLCTAVKAISSAVRKAGIAHLYGIAGSTNVTGDQVKKLDVLSNDLVMNMLKSSFATCVLVSEEDKHAIIVEPEKRGKYVVCFDPLDGSSNIDCLVSVGTIFGIYRKKSTDEPSEKDALQPGRNLVAAGYALYGSATMLVLAMDCGVNCFMLDPAIGEFILVDKDVKIKKKGKIYSLNEGYARDFDPAVTEYIQRKKFPPDNSAPYGARYVGSMVADVHRTLVYGGIFLYPANKKSPNGKLRLLYECNPMAYVMEKAGGMATTGKEAVLDVIPTDIHQRAPVILGSPDDVLEFLKVYEKHSAQ
  
Inhibitor
Name:
BDBM50095261
Synonyms:
(3-Chloro-phenyl)-(6,7-diethoxy-quinazolin-4-yl)-amine | 4-(3'-chloroanilino)-6,7-diethoxyquinazoline hydrochloride | CHEMBL64950
Type:
Small organic molecule
Emp. Form.:
C18H18ClN3O2
Mol. Mass.:
343.807
SMILES:
CCOc1cc2ncnc(Nc3cccc(Cl)c3)c2cc1OCC
Structure:
Search PDB for entries with ligand similarity: