Reaction Details Report a problem with these data
Target
C-C chemokine receptor type 2
Ligand
BDBM50371414
Substrate
n/a
Meas. Tech.
ChEMBL_463346 (CHEMBL929489)
IC50
0.5±n/a nM
Citation
 Cherney, RJ; Mo, R; Meyer, DT; Nelson, DJ; Lo, YC; Yang, G; Scherle, PA; Mandlekar, S; Wasserman, ZR; Jezak, H; Solomon, KA; Tebben, AJ; Carter, PH; Decicco, CP Discovery of disubstituted cyclohexanes as a new class of CC chemokine receptor 2 antagonists. J Med Chem 51:721-4 (2008) [PubMed]  Article 
Target
Name:
C-C chemokine receptor type 2
Synonyms:
C-C chemokine receptor type 2 (CCR2) | CCR2 | CCR2_HUMAN | CMKBR2 | Chemoattractant Cytokine Receptor 2 (CCR2) | Chemokine Receptor Type 2b (CCR2b) | Monocyte chemotactic protein-1 (MCP-1)
Type:
Enzyme
Mol. Mass.:
41932.32
Organism:
Homo sapiens (Human)
Description:
P41597
Residue:
374
Sequence:
MLSTSRSRFIRNTNESGEEVTTFFDYDYGAPCHKFDVKQIGAQLLPPLYSLVFIFGFVGNMLVVLILINCKKLKCLTDIYLLNLAISDLLFLITLPLWAHSAANEWVFGNAMCKLFTGLYHIGYFGGIFFIILLTIDRYLAIVHAVFALKARTVTFGVVTSVITWLVAVFASVPGIIFTKCQKEDSVYVCGPYFPRGWNNFHTIMRNILGLVLPLLIMVICYSGILKTLLRCRNEKKRHRAVRVIFTIMIVYFLFWTPYNIVILLNTFQEFFGLSNCESTSQLDQATQVTETLGMTHCCINPIIYAFVGEKFRSLFHIALGCRIAPLQKPVCGGPGVRPGKNVKVTTQGLLDGRGKGKSIGRAPEASLQDKEGA
  
Inhibitor
Name:
BDBM50371414
Synonyms:
CHEMBL271828
Type:
Small organic molecule
Emp. Form.:
C30H36F3N5O6S
Mol. Mass.:
651.697
SMILES:
NS(=O)(=O)c1ccc(cc1)C(=O)N[C@@H]1CCCC[C@@H]1NC(=O)CNC(=O)c1cc(ccc1NC(=O)C1CCCCC1)C(F)(F)F
Structure:
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