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Target
DNA polymerase beta
Ligand
BDBM50375301
Substrate
n/a
Meas. Tech.
ChEMBL_470719 (CHEMBL934559)
IC50
11900±n/a nM
Citation
 Naganuma, M; Nishida, M; Kuramochi, K; Sugawara, F; Yoshida, H; Mizushina, Y 1-deoxyrubralactone, a novel specific inhibitor of families X and Y of eukaryotic DNA polymerases from a fungal strain derived from sea algae. Bioorg Med Chem 16:2939-44 (2008) [PubMed]  Article 
Target
Name:
DNA polymerase beta
Synonyms:
DNA Polymerase beta | DPOLB_RAT | Polb
Type:
PROTEIN
Mol. Mass.:
38334.34
Organism:
Rattus norvegicus
Description:
ChEMBL_1361926
Residue:
335
Sequence:
MSKRKAPQETLNGGITDMLVELANFEKNVSQAIHKYNAYRKAASVIAKYPHKIKSGAEAKKLPGVGTKIAEKIDEFLATGKLRKLEKIRQDDTSSSINFLTRVTGIGPSAARKLVDEGIKTLEDLRKNEDKLNHHQRIGLKYFEDFEKRIPREEMLQMQDIVLNEVKKLDPEYIATVCGSFRRGAESSGDMDVLLTHPNFTSESSKQPKLLHRVVEQLQKVRFITDTLSKGETKFMGVCQLPSENDENEYPHRRIDIRLIPKDQYYCGVLYFTGSDIFNKNMRAHALEKGFTINEYTIRPLGVTGVAGEPLPVDSEQDIFDYIQWRYREPKDRSE
  
Inhibitor
Name:
BDBM50375301
Synonyms:
CHEMBL260980
Type:
Small organic molecule
Emp. Form.:
C14H12O5
Mol. Mass.:
260.2421
SMILES:
COc1cc(O)c2c(c1)c1C(C)CC(=O)c1oc2=O
Structure:
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