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Target
Small conductance calcium-activated potassium channel protein 3
Ligand
BDBM50199404
Substrate
n/a
Meas. Tech.
ChEMBL_494975 (CHEMBL1008047)
Kd
2600±n/a nM
Citation
Sørensen, US; Strøbaek, D; Christophersen, P; Hougaard, C; Jensen, ML; Nielsen, EŘ; Peters, D; Teuber, L Synthesis and structure-activity relationship studies of 2-(N-substituted)-aminobenzimidazoles as potent negative gating modulators ofsmall conductance Ca2+-activated K+ channels. J Med Chem 51:7625-34 (2009) [PubMed] Article
More Info.:
Target
Name:
Small conductance calcium-activated potassium channel protein 3
Synonyms:
KCNN3_RAT | Kcnn3 | SK3 | Small conductance calcium-activated potassium channel
Type:
PROTEIN
Mol. Mass.:
81476.29
Organism:
Rat
Description:
ChEMBL_494975
Residue:
732
Sequence:
MDTSGHFHDSGVGDLDEDPKCPCPSSGDEQQQQQQPPPPSAPPAVPQQPPGPLLQPQPPQLQQQQQQQQQQQQQQQQQQQAPLHPLPQLAQLQSQLVHPGLLHSSPTAFRAPNSANSTAILHPSSRQGSQLNLNDHLLGHSPSSTATSGPGGGSRHRQASPLVHRRDSNPFTEIAMSSCKYSGGVMKPLSRLSASRRNLIEAEPEGQPLQLFSPSNPPEIIISSREDNHAHQTLLHHPNATHNHQHAGTTAGSTTFPKANKRKNQNIGYKLGHRRALFEKRKRLSDYALIFGMFGIVVMVIETELSWGLYSKDSMFSLALKCLISLSTIILLGLIIAYHTREVQLFVIDNGADDWRIAMTYERILYISLEMLVCAIHPIPGEYKFFWTARLAFSYTPSRAEADVDIILSIPMFLRLYLIARVMLLHSKLFTDASSRSIGALNKINFNTRFVMKTLMTICPGTVLLVFSISLWIIAAWTVRVCERYHDQQDVTSNFLGAMWLISITFLSIGYGDMVPHTYCGKGVCLLTGIMGAGCTALVVAVVARKLELTKAEKHVHNFMMDTQLTKRIKNAAANVLRETWLIYKHTKLLKKIDHAKVRKHQRKFLQAIHQLRGVKMEQRKLSDQANTLVDLSKMQNVMYDLITELNDRSEDLEKQIGSLESKLEHLTASFNSLPLLIADTLRQQQQQLLTAFVEARGISVAVGTSHAPPSDSPIGISSTSFPTPYTSSSSC
Inhibitor
Name:
BDBM50199404
Synonyms:
1-(3,4-Dimethoxy-benzyl)-6,7-dimethoxy-2,2-dimethyl-1,2,3,4-tetrahydro-isoquinolinium iodide | 1-(3,4-Dimethoxy-benzyl)-6,7-dimethoxy-2,2-dimethyl-1,2,3,4-tetrahydro-isoquinolinium; iodide | CHEMBL215370 | N-Me-laudanosine | N-methyl-laudanosine
Type:
Small organic molecule
Emp. Form.:
C22H30NO4
Mol. Mass.:
372.4774
SMILES:
COc1ccc(C[C@H]2c3cc(OC)c(OC)cc3CC[N+]2(C)C)cc1OC