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Target
Purine nucleoside phosphorylase
Ligand
BDBM22103
Substrate
n/a
Meas. Tech.
ChEMBL_519471 (CHEMBL951777)
Ki
0.229±n/a nM
Citation
 Clinch, K; Evans, GB; Fröhlich, RF; Furneaux, RH; Kelly, PM; Legentil, L; Murkin, AS; Li, L; Schramm, VL; Tyler, PC; Woolhouse, AD Third-generation immucillins: syntheses and bioactivities of acyclic immucillin inhibitors of human purine nucleoside phosphorylase. J Med Chem 52:1126-43 (2009) [PubMed]  Article 
Target
Name:
Purine nucleoside phosphorylase
Synonyms:
Inosine phosphorylase | Inosine-guanosine phosphorylase | NP | PNP | PNPH_HUMAN | Purine nucleoside phosphorylase (PNPase)
Type:
Enzyme
Mol. Mass.:
32119.53
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
289
Sequence:
MENGYTYEDYKNTAEWLLSHTKHRPQVAIICGSGLGGLTDKLTQAQIFDYGEIPNFPRSTVPGHAGRLVFGFLNGRACVMMQGRFHMYEGYPLWKVTFPVRVFHLLGVDTLVVTNAAGGLNPKFEVGDIMLIRDHINLPGFSGQNPLRGPNDERFGDRFPAMSDAYDRTMRQRALSTWKQMGEQRELQEGTYVMVAGPSFETVAECRVLQKLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESLEKANHEEVLAAGKQAAQKLEQFVSILMASIPLPDKAS
  
Inhibitor
Name:
BDBM22103
Synonyms:
7-{[3,3-bis(hydroxymethyl)azetidin-1-yl]methyl}-3H,4H,5H-pyrrolo[3,2-d]pyrimidin-4-one | Azetidine based compound, 34
Type:
Small organic molecule
Emp. Form.:
C12H16N4O3
Mol. Mass.:
264.2804
SMILES:
OCC1(CO)CN(Cc2c[nH]c3c2nc[nH]c3=O)C1
Structure:
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