Reaction Details Report a problem with these data
Target
Dual specificity protein phosphatase 3
Ligand
BDBM50388823
Substrate
n/a
Meas. Tech.
ChEMBL_830918 (CHEMBL2065467)
IC50
4690±n/a nM
Citation
 Tsuchiya, A; Hirai, G; Koyama, Y; Oonuma, K; Otani, Y; Osada, H; Sodeoka, M Dual-Specificity Phosphatase CDC25A/B Inhibitor Identified from a Focused Library with Nonelectrophilic Core Structure. ACS Med Chem Lett 3:294-298 (2012) [PubMed]  Article 
Target
Name:
Dual specificity protein phosphatase 3
Synonyms:
DUS3_HUMAN | DUSP3 | Dual specificity protein phosphatase (VHR) | Dual specificity protein phosphatase 3 | Dual specificity protein phosphatase VHR | Protein Tyrosine Phosphatase VHR | Tyrosine-protein phosphatase non-receptor type 1 | VHR
Type:
Hydrolase
Mol. Mass.:
20480.58
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
185
Sequence:
MSGSFELSVQDLNDLLSDGSGCYSLPSQPCNEVTPRIYVGNASVAQDIPKLQKLGITHVLNAAEGRSFMHVNTNANFYKDSGITYLGIKANDTQEFNLSAYFERAADFIDQALAQKNGRVLVHCREGYSRSPTLVIAYLMMRQKMDVKSALSIVRQNREIGPNDGFLAQLCQLNDRLAKEGKLKP
  
Inhibitor
Name:
BDBM50388823
Synonyms:
CHEMBL2062593
Type:
Small organic molecule
Emp. Form.:
C28H42FNO4
Mol. Mass.:
475.6358
SMILES:
CCCCCCCCCCCCCCCC(NCc1cccc(F)c1)=C1C(=O)OC(CO)C1=O |w:15.15|
Structure:
Search PDB for entries with ligand similarity: