Reaction Details Report a problem with these data
Target
Neuropeptide Y receptor type 1
Ligand
BDBM50436463
Substrate
n/a
Meas. Tech.
ChEMBL_967923 (CHEMBL2400739)
IC50
4380±n/a nM
Citation
 Luo, G; Chen, L; Hu, S; Huang, Y; Mattson, G; Iben, LG; Russell, JW; Clarke, WJ; Hogan, JB; Antal-Zimanyi, I; Poindexter, GS Heterocyclic modification of a novel bicyclo[3.1.0]hexane NPY1 receptor antagonist. Bioorg Med Chem Lett 23:3814-7 (2013) [PubMed]  Article 
Target
Name:
Neuropeptide Y receptor type 1
Synonyms:
NPY-Y1 | NPY1-R | NPY1R | NPY1R_HUMAN | NPYR | NPYY1 | neuropeptide Y receptor Y1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
44399.07
Organism:
Homo sapiens (Human)
Description:
NPY-Y1 NPY1R HUMAN::P25929
Residue:
384
Sequence:
MNSTLFSQVENHSVHSNFSEKNAQLLAFENDDCHLPLAMIFTLALAYGAVIILGVSGNLALIIIILKQKEMRNVTNILIVNLSFSDLLVAIMCLPFTFVYTLMDHWVFGEAMCKLNPFVQCVSITVSIFSLVLIAVERHQLIINPRGWRPNNRHAYVGIAVIWVLAVASSLPFLIYQVMTDEPFQNVTLDAYKDKYVCFDQFPSDSHRLSYTTLLLVLQYFGPLCFIFICYFKIYIRLKRRNNMMDKMRDNKYRSSETKRINIMLLSIVVAFAVCWLPLTIFNTVFDWNHQIIATCNHNLLFLLCHLTAMISTCVNPIFYGFLNKNFQRDLQFFFNFCDFRSRDDDYETIAMSTMHTDVSKTSLKQASPVAFKKINNNDDNEKI
  
Inhibitor
Name:
BDBM50436463
Synonyms:
CHEMBL2397294
Type:
Small organic molecule
Emp. Form.:
C23H30N4O
Mol. Mass.:
378.5105
SMILES:
CCOc1cccc(c1)C1(C2CC(C)CC12)N1CCN(CC1)c1cccnn1 |(21.7,-21.74,;20.21,-21.34,;19.12,-22.44,;17.64,-22.05,;17.23,-20.55,;15.72,-20.16,;14.64,-21.26,;15.05,-22.75,;16.55,-23.15,;13.96,-23.85,;12.46,-24.16,;10.92,-24.17,;10.45,-22.71,;8.98,-22.23,;11.69,-21.8,;12.94,-22.71,;14.36,-25.33,;13.27,-26.41,;13.66,-27.89,;15.14,-28.3,;16.23,-27.21,;15.84,-25.72,;15.53,-29.78,;17.02,-30.18,;17.42,-31.67,;16.32,-32.76,;14.84,-32.35,;14.44,-30.87,)|
Structure:
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