Reaction Details Report a problem with these data
Target
Neuropeptide Y receptor type 1
Ligand
BDBM50436464
Substrate
n/a
Meas. Tech.
ChEMBL_967923 (CHEMBL2400739)
IC50
4270±n/a nM
Citation
 Luo, G; Chen, L; Hu, S; Huang, Y; Mattson, G; Iben, LG; Russell, JW; Clarke, WJ; Hogan, JB; Antal-Zimanyi, I; Poindexter, GS Heterocyclic modification of a novel bicyclo[3.1.0]hexane NPY1 receptor antagonist. Bioorg Med Chem Lett 23:3814-7 (2013) [PubMed]  Article 
Target
Name:
Neuropeptide Y receptor type 1
Synonyms:
NPY-Y1 | NPY1-R | NPY1R | NPY1R_HUMAN | NPYR | NPYY1 | neuropeptide Y receptor Y1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
44399.07
Organism:
Homo sapiens (Human)
Description:
NPY-Y1 NPY1R HUMAN::P25929
Residue:
384
Sequence:
MNSTLFSQVENHSVHSNFSEKNAQLLAFENDDCHLPLAMIFTLALAYGAVIILGVSGNLALIIIILKQKEMRNVTNILIVNLSFSDLLVAIMCLPFTFVYTLMDHWVFGEAMCKLNPFVQCVSITVSIFSLVLIAVERHQLIINPRGWRPNNRHAYVGIAVIWVLAVASSLPFLIYQVMTDEPFQNVTLDAYKDKYVCFDQFPSDSHRLSYTTLLLVLQYFGPLCFIFICYFKIYIRLKRRNNMMDKMRDNKYRSSETKRINIMLLSIVVAFAVCWLPLTIFNTVFDWNHQIIATCNHNLLFLLCHLTAMISTCVNPIFYGFLNKNFQRDLQFFFNFCDFRSRDDDYETIAMSTMHTDVSKTSLKQASPVAFKKINNNDDNEKI
  
Inhibitor
Name:
BDBM50436464
Synonyms:
CHEMBL2397293
Type:
Small organic molecule
Emp. Form.:
C22H29N5O
Mol. Mass.:
379.4986
SMILES:
CCOc1cccc(c1)C1(C2CC(C)CC12)N1CCN(CC1)c1ncncn1 |(27.99,-16.3,;26.5,-15.91,;25.41,-17.01,;23.93,-16.61,;23.52,-15.12,;22.01,-14.73,;20.93,-15.83,;21.34,-17.32,;22.84,-17.71,;20.25,-18.42,;18.75,-18.73,;17.21,-18.74,;16.74,-17.28,;15.27,-16.8,;17.98,-16.37,;19.23,-17.28,;20.65,-19.9,;19.56,-20.98,;19.95,-22.46,;21.43,-22.86,;22.52,-21.78,;22.13,-20.29,;21.82,-24.35,;20.73,-25.43,;21.12,-26.92,;22.6,-27.33,;23.7,-26.23,;23.3,-24.75,)|
Structure:
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