Reaction Details Report a problem with these data
Target
Neuropeptide Y receptor type 1
Ligand
BDBM50436468
Substrate
n/a
Meas. Tech.
ChEMBL_967923 (CHEMBL2400739)
IC50
265±n/a nM
Citation
 Luo, G; Chen, L; Hu, S; Huang, Y; Mattson, G; Iben, LG; Russell, JW; Clarke, WJ; Hogan, JB; Antal-Zimanyi, I; Poindexter, GS Heterocyclic modification of a novel bicyclo[3.1.0]hexane NPY1 receptor antagonist. Bioorg Med Chem Lett 23:3814-7 (2013) [PubMed]  Article 
Target
Name:
Neuropeptide Y receptor type 1
Synonyms:
NPY-Y1 | NPY1-R | NPY1R | NPY1R_HUMAN | NPYR | NPYY1 | neuropeptide Y receptor Y1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
44399.07
Organism:
Homo sapiens (Human)
Description:
NPY-Y1 NPY1R HUMAN::P25929
Residue:
384
Sequence:
MNSTLFSQVENHSVHSNFSEKNAQLLAFENDDCHLPLAMIFTLALAYGAVIILGVSGNLALIIIILKQKEMRNVTNILIVNLSFSDLLVAIMCLPFTFVYTLMDHWVFGEAMCKLNPFVQCVSITVSIFSLVLIAVERHQLIINPRGWRPNNRHAYVGIAVIWVLAVASSLPFLIYQVMTDEPFQNVTLDAYKDKYVCFDQFPSDSHRLSYTTLLLVLQYFGPLCFIFICYFKIYIRLKRRNNMMDKMRDNKYRSSETKRINIMLLSIVVAFAVCWLPLTIFNTVFDWNHQIIATCNHNLLFLLCHLTAMISTCVNPIFYGFLNKNFQRDLQFFFNFCDFRSRDDDYETIAMSTMHTDVSKTSLKQASPVAFKKINNNDDNEKI
  
Inhibitor
Name:
BDBM50436468
Synonyms:
CHEMBL2397200
Type:
Small organic molecule
Emp. Form.:
C23H30N4O
Mol. Mass.:
378.5105
SMILES:
CCOc1cccc(c1)C1(C2CC(C)CC12)N1CCN(CC1)c1cnccn1 |(16.59,-16.93,;15.1,-16.54,;14.02,-17.64,;12.53,-17.24,;12.12,-15.75,;10.62,-15.36,;9.53,-16.46,;9.94,-17.95,;11.44,-18.34,;8.86,-19.05,;7.36,-19.36,;5.81,-19.37,;5.34,-17.9,;3.88,-17.43,;6.58,-17,;7.83,-17.9,;9.25,-20.53,;8.16,-21.61,;8.55,-23.09,;10.03,-23.49,;11.12,-22.41,;10.73,-20.92,;10.43,-24.98,;9.33,-26.06,;9.72,-27.55,;11.21,-27.95,;12.31,-26.86,;11.91,-25.38,)|
Structure:
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