Reaction Details Report a problem with these data
Target
Neuropeptide Y receptor type 1
Ligand
BDBM50436470
Substrate
n/a
Meas. Tech.
ChEMBL_967923 (CHEMBL2400739)
IC50
>10000±n/a nM
Citation
 Luo, G; Chen, L; Hu, S; Huang, Y; Mattson, G; Iben, LG; Russell, JW; Clarke, WJ; Hogan, JB; Antal-Zimanyi, I; Poindexter, GS Heterocyclic modification of a novel bicyclo[3.1.0]hexane NPY1 receptor antagonist. Bioorg Med Chem Lett 23:3814-7 (2013) [PubMed]  Article 
Target
Name:
Neuropeptide Y receptor type 1
Synonyms:
NPY-Y1 | NPY1-R | NPY1R | NPY1R_HUMAN | NPYR | NPYY1 | neuropeptide Y receptor Y1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
44399.07
Organism:
Homo sapiens (Human)
Description:
NPY-Y1 NPY1R HUMAN::P25929
Residue:
384
Sequence:
MNSTLFSQVENHSVHSNFSEKNAQLLAFENDDCHLPLAMIFTLALAYGAVIILGVSGNLALIIIILKQKEMRNVTNILIVNLSFSDLLVAIMCLPFTFVYTLMDHWVFGEAMCKLNPFVQCVSITVSIFSLVLIAVERHQLIINPRGWRPNNRHAYVGIAVIWVLAVASSLPFLIYQVMTDEPFQNVTLDAYKDKYVCFDQFPSDSHRLSYTTLLLVLQYFGPLCFIFICYFKIYIRLKRRNNMMDKMRDNKYRSSETKRINIMLLSIVVAFAVCWLPLTIFNTVFDWNHQIIATCNHNLLFLLCHLTAMISTCVNPIFYGFLNKNFQRDLQFFFNFCDFRSRDDDYETIAMSTMHTDVSKTSLKQASPVAFKKINNNDDNEKI
  
Inhibitor
Name:
BDBM50436470
Synonyms:
CHEMBL2397301
Type:
Small organic molecule
Emp. Form.:
C19H28N2O
Mol. Mass.:
300.4384
SMILES:
CCOc1cccc(c1)C1(C2CC(C)CC12)N1CCNCC1 |(49.56,-3.76,;48.07,-3.37,;46.98,-4.47,;45.49,-4.08,;45.09,-2.58,;43.58,-2.19,;42.5,-3.29,;42.91,-4.78,;44.41,-5.18,;41.82,-5.88,;40.32,-6.19,;38.78,-6.2,;38.31,-4.74,;36.84,-4.26,;39.55,-3.83,;40.8,-4.74,;42.22,-7.36,;41.13,-8.44,;41.52,-9.92,;43,-10.33,;44.09,-9.24,;43.7,-7.75,)|
Structure:
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