Reaction Details Report a problem with these data
Target
Neuropeptide Y receptor type 1
Ligand
BDBM50436475
Substrate
n/a
Meas. Tech.
ChEMBL_967923 (CHEMBL2400739)
IC50
892±n/a nM
Citation
 Luo, G; Chen, L; Hu, S; Huang, Y; Mattson, G; Iben, LG; Russell, JW; Clarke, WJ; Hogan, JB; Antal-Zimanyi, I; Poindexter, GS Heterocyclic modification of a novel bicyclo[3.1.0]hexane NPY1 receptor antagonist. Bioorg Med Chem Lett 23:3814-7 (2013) [PubMed]  Article 
Target
Name:
Neuropeptide Y receptor type 1
Synonyms:
NPY-Y1 | NPY1-R | NPY1R | NPY1R_HUMAN | NPYR | NPYY1 | neuropeptide Y receptor Y1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
44399.07
Organism:
Homo sapiens (Human)
Description:
NPY-Y1 NPY1R HUMAN::P25929
Residue:
384
Sequence:
MNSTLFSQVENHSVHSNFSEKNAQLLAFENDDCHLPLAMIFTLALAYGAVIILGVSGNLALIIIILKQKEMRNVTNILIVNLSFSDLLVAIMCLPFTFVYTLMDHWVFGEAMCKLNPFVQCVSITVSIFSLVLIAVERHQLIINPRGWRPNNRHAYVGIAVIWVLAVASSLPFLIYQVMTDEPFQNVTLDAYKDKYVCFDQFPSDSHRLSYTTLLLVLQYFGPLCFIFICYFKIYIRLKRRNNMMDKMRDNKYRSSETKRINIMLLSIVVAFAVCWLPLTIFNTVFDWNHQIIATCNHNLLFLLCHLTAMISTCVNPIFYGFLNKNFQRDLQFFFNFCDFRSRDDDYETIAMSTMHTDVSKTSLKQASPVAFKKINNNDDNEKI
  
Inhibitor
Name:
BDBM50436475
Synonyms:
CHEMBL2397295
Type:
Small organic molecule
Emp. Form.:
C24H31N3O
Mol. Mass.:
377.5224
SMILES:
CCOc1cccc(c1)C1(C2CC(C)CC12)N1CCN(CC1)c1cccnc1 |(21.2,-22.5,;19.71,-22.11,;18.62,-23.21,;17.13,-22.82,;16.73,-21.32,;15.22,-20.93,;14.14,-22.03,;14.55,-23.52,;16.05,-23.92,;13.46,-24.62,;11.96,-24.93,;10.42,-24.94,;9.95,-23.48,;8.48,-23,;11.19,-22.57,;12.44,-23.48,;13.86,-26.1,;12.77,-27.18,;13.16,-28.66,;14.64,-29.07,;15.73,-27.98,;15.34,-26.49,;15.03,-30.55,;13.94,-31.64,;14.33,-33.13,;15.81,-33.53,;16.91,-32.45,;16.52,-30.96,)|
Structure:
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