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Target
Lipoprotein lipase
Ligand
BDBM50444153
Substrate
n/a
Meas. Tech.
ChEMBL_1280894 (CHEMBL3095192)
IC50
2560±n/a nM
Citation
 Sun, S; Dean, R; Jia, Q; Zenova, A; Zhong, J; Grayson, C; Xie, C; Lindgren, A; Samra, P; Sojo, L; van Heek, M; Lin, L; Percival, D; Fu, JM; Winther, MD; Zhang, Z Discovery of XEN445: a potent and selective endothelial lipase inhibitor raises plasma HDL-cholesterol concentration in mice. Bioorg Med Chem 21:7724-34 (2013) [PubMed]  Article 
Target
Name:
Lipoprotein lipase
Synonyms:
LIPD | LIPL_HUMAN | LPL
Type:
PROTEIN
Mol. Mass.:
53173.96
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1280894
Residue:
475
Sequence:
MESKALLVLTLAVWLQSLTASRGGVAAADQRRDFIDIESKFALRTPEDTAEDTCHLIPGVAESVATCHFNHSSKTFMVIHGWTVTGMYESWVPKLVAALYKREPDSNVIVVDWLSRAQEHYPVSAGYTKLVGQDVARFINWMEEEFNYPLDNVHLLGYSLGAHAAGIAGSLTNKKVNRITGLDPAGPNFEYAEAPSRLSPDDADFVDVLHTFTRGSPGRSIGIQKPVGHVDIYPNGGTFQPGCNIGEAIRVIAERGLGDVDQLVKCSHERSIHLFIDSLLNEENPSKAYRCSSKEAFEKGLCLSCRKNRCNNLGYEINKVRAKRSSKMYLKTRSQMPYKVFHYQVKIHFSGTESETHTNQAFEISLYGTVAESENIPFTLPEVSTNKTYSFLIYTEVDIGELLMLKLKWKSDSYFSWSDWWSSPGFAIQKIRVKAGETQKKVIFCSREKVSHLQKGKAPAVFVKCHDKSLNKKSG
  
Inhibitor
Name:
BDBM50444153
Synonyms:
CHEMBL3093304
Type:
Small organic molecule
Emp. Form.:
C19H17F4NO2
Mol. Mass.:
367.3374
SMILES:
OC(=O)c1cc(ccc1N1CCC(Cc2ccc(F)cc2)C1)C(F)(F)F
Structure:
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