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Target
Serine/threonine-protein kinase N1
Ligand
BDBM50028031
Substrate
n/a
Meas. Tech.
ChEMBL_1433150 (CHEMBL3387550)
IC50
>1000±n/a nM
Citation
 Shaw, D; Hollingworth, G; Soldermann, N; Sprague, E; Schuler, W; Vangrevelinghe, E; Duggan, N; Thomas, M; Kosaka, T; Waters, N; van Eis, MJ Novel ROCK inhibitors for the treatment of pulmonary arterial hypertension. Bioorg Med Chem Lett 24:4812-7 (2014) [PubMed]  Article 
Target
Name:
Serine/threonine-protein kinase N1
Synonyms:
PAK1 | PKN | PKN1 | PKN1_HUMAN | PRK1 | PRKCL1 | Protein kinase N1 | Serine/threonine-protein kinase N1/Transforming protein RhoA
Type:
PROTEIN
Mol. Mass.:
103928.39
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1433150
Residue:
942
Sequence:
MASDAVQSEPRSWSLLEQLGLAGADLAAPGVQQQLELERERLRREIRKELKLKEGAENLRRATTDLGRSLGPVELLLRGSSRRLDLLHQQLQELHAHVVLPDPAATHDGPQSPGAGGPTCSATNLSRVAGLEKQLAIELKVKQGAENMIQTYSNGSTKDRKLLLTAQQMLQDSKTKIDIIRMQLRRALQAGQLENQAAPDDTQGSPDLGAVELRIEELRHHFRVEHAVAEGAKNVLRLLSAAKAPDRKAVSEAQEKLTESNQKLGLLREALERRLGELPADHPKGRLLREELAAASSAAFSTRLAGPFPATHYSTLCKPAPLTGTLEVRVVGCRDLPETIPWNPTPSMGGPGTPDSRPPFLSRPARGLYSRSGSLSGRSSLKAEAENTSEVSTVLKLDNTVVGQTSWKPCGPNAWDQSFTLELERARELELAVFWRDQRGLCALKFLKLEDFLDNERHEVQLDMEPQGCLVAEVTFRNPVIERIPRLRRQKKIFSKQQGKAFQRARQMNIDVATWVRLLRRLIPNATGTGTFSPGASPGSEARTTGDISVEKLNLGTDSDSSPQKSSRDPPSSPSSLSSPIQESTAPELPSETQETPGPALCSPLRKSPLTLEDFKFLAVLGRGHFGKVLLSEFRPSGELFAIKALKKGDIVARDEVESLMCEKRILAAVTSAGHPFLVNLFGCFQTPEHVCFVMEYSAGGDLMLHIHSDVFSEPRAIFYSACVVLGLQFLHEHKIVYRDLKLDNLLLDTEGYVKIADFGLCKEGMGYGDRTSTFCGTPEFLAPEVLTDTSYTRAVDWWGLGVLLYEMLVGESPFPGDDEEEVFDSIVNDEVRYPRFLSAEAIGIMRRLLRRNPERRLGSSERDAEDVKKQPFFRTLGWEALLARRLPPPFVPTLSGRTDVSNFDEEFTGEAPTLSPPRDARPLTAAEQAAFLDFDFVAGGC
  
Inhibitor
Name:
BDBM50028031
Synonyms:
CHEMBL3338843
Type:
Small organic molecule
Emp. Form.:
C18H18N6
Mol. Mass.:
318.3757
SMILES:
NCCCNc1nc(nc2ccccc12)-c1ccc2[nH]ncc2c1
Structure:
Search PDB for entries with ligand similarity: