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Target
Indoleamine 2,3-dioxygenase 1
Ligand
BDBM70489
Substrate
n/a
Meas. Tech.
ChEMBL_1524692 (CHEMBL3631086)
IC50
4612±n/a nM
Citation
 Wu, JS; Lin, SY; Liao, FY; Hsiao, WC; Lee, LC; Peng, YH; Hsieh, CL; Wu, MH; Song, JS; Yueh, A; Chen, CH; Yeh, SH; Liu, CY; Lin, SY; Yeh, TK; Hsu, JT; Shih, C; Ueng, SH; Hung, MS; Wu, SY Identification of Substituted Naphthotriazolediones as Novel Tryptophan 2,3-Dioxygenase (TDO) Inhibitors through Structure-Based Virtual Screening. J Med Chem 58:7807-19 (2015) [PubMed]  Article 
Target
Name:
Indoleamine 2,3-dioxygenase 1
Synonyms:
I23O1_HUMAN | IDO | IDO-1 | IDO1 | INDO | Indoleamine 2,3-Dioxygenasae (IDO) | Indoleamine 2,3-dioxygenase | Indoleamine-pyrrole 2,3-dioxygenase
Type:
Enzyme
Mol. Mass.:
45330.80
Organism:
Homo sapiens (Human)
Description:
P14902
Residue:
403
Sequence:
MAHAMENSWTISKEYHIDEEVGFALPNPQENLPDFYNDWMFIAKHLPDLIESGQLRERVEKLNMLSIDHLTDHKSQRLARLVLGCITMAYVWGKGHGDVRKVLPRNIAVPYCQLSKKLELPPILVYADCVLANWKKKDPNKPLTYENMDVLFSFRDGDCSKGFFLVSLLVEIAAASAIKVIPTVFKAMQMQERDTLLKALLEIASCLEKALQVFHQIHDHVNPKAFFSVLRIYLSGWKGNPQLSDGLVYEGFWEDPKEFAGGSAGQSSVFQCFDVLLGIQQTAGGGHAAQFLQDMRRYMPPAHRNFLCSLESNPSVREFVLSKGDAGLREAYDACVKALVSLRSYHLQIVTKYILIPASQQPKENKTSEDPSKLEAKGTGGTDLMNFLKTVRSTTEKSLLKEG
  
Inhibitor
Name:
BDBM70489
Synonyms:
1-(3-methylbenzyl)-1H-naphtho[2,3-d][1,2,3]triazole-4,9-dione | 3-(3-methylbenzyl)benzo[f]benzotriazole-4,9-quinone | 3-[(3-methylphenyl)methyl]benzo[f]benzotriazole-4,9-dione | MLS000594471 | SMR000115594 | cid_849734
Type:
Small organic molecule
Emp. Form.:
C18H13N3O2
Mol. Mass.:
303.3147
SMILES:
Cc1cccc(Cn2nnc3c2C(=O)c2ccccc2C3=O)c1
Structure:
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