Reaction Details
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Adenosine receptor A2b
Ligand
BDBM50232078
Substrate
n/a
Meas. Tech.
ChEMBL_1646018 (CHEMBL3995074)
Ki
1.8±n/a nM
Citation
Basu, S; Barawkar, DA; Ramdas, V; Waman, Y; Patel, M; Panmand, A; Kumar, S; Thorat, S; Bonagiri, R; Jadhav, D; Mukhopadhyay, P; Prasad, V; Reddy, BS; Goswami, A; Chaturvedi, S; Menon, S; Quraishi, A; Ghosh, I; Dusange, S; Paliwal, S; Kulkarni, A; Karande, V; Thakre, R; Bedse, G; Rouduri, S; Gundu, J; Palle, VP; Chugh, A; Mookhtiar, KA A Eur J Med Chem 127:986-996 (2017) [PubMed] Article More Info.:
Target
Name:
Adenosine receptor A2b
Synonyms:
AA2BR_HUMAN | ADENOSINE A2B | ADORA2B | Adenosine receptor A2B (A2B) | Adenosine receptors A2b | Adenosine receptors; A2a & A2b
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
36341.22
Organism:
Human
Description:
n/a
Residue:
332
Sequence:
MLLETQDALYVALELVIAALSVAGNVLVCAAVGTANTLQTPTNYFLVSLAAADVAVGLFAIPFAITISLGFCTDFYGCLFLACFVLVLTQSSIFSLLAVAVDRYLAICVPLRYKSLVTGTRARGVIAVLWVLAFGIGLTPFLGWNSKDSATNNCTEPWDGTTNESCCLVKCLFENVVPMSYMVYFNFFGCVLPPLLIMLVIYIKIFLVACRQLQRTELMDHSRTTLQREIHAAKSLAMIVGIFALCWLPVHAVNCVTLFQPAQGKNKPKWAMNMAILLSHANSVVNPIVYAYRNRDFRYTFHKIISRYLLCQADVKSGNGQAGVQPALGVGL
Inhibitor
Name:
BDBM50232078
Synonyms:
CHEMBL4080171
Type:
Small organic molecule
Emp. Form.:
C26H30ClFN8O3
Mol. Mass.:
557.02
SMILES:
CCCn1c2nc([nH]c2c(=O)n(CCC)c1=O)-c1cnn(CC(=O)N2CCN(CC2)c2ccc(F)c(Cl)c2)c1
Structure:
