Reaction Details
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Calcium-activated potassium channel subunit beta
Ligand
BDBM86250
Substrate
n/a
Ki
10.72±n/a nM
Comments
PDSP_3709
Citation
Gopalakrishnan, M; Buckner, SA; Shieh, CC; Fey, T; Fabiyi, A; Whiteaker, KL; Davis-Taber, R; Milicic, I; Daza, AV; Scott, VE; Castle, NA; Printzenhoff, D; London, B; Turner, SC; Carroll, WA; Sullivan, JP; Coghlan, MJ; Brune, ME In vitro and in vivo characterization of a novel naphthylamide ATP-sensitive K+ channel opener, A-151892. Br J Pharmacol 143:81-90 (2004) [PubMed] Article More Info.:
Target
Name:
Calcium-activated potassium channel subunit beta
Synonyms:
Potassium channel (ATP modulatory)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
22836.62
Organism:
GUINEA PIG
Description:
C0KY85
Residue:
199
Sequence:
GSHAKPFMLSTQREESNCTIIHTHIMDDWMDCAFTCGVDCQGQGKYPCLQVFVNLTHSGQKALLHYNEEAVQINSKCFYTPKCRRDGNDLLNSALNIKEFFDHKNRTPFSCFYSPDNQSEDVILIKKYDQMVIFHCLFWPSMTMLGGALIVGMVRLTQYLFLLCEKYSTALRDEVSGKVPYVARNQFKLWSVGRSKGRA
Inhibitor
Name:
BDBM86250
Synonyms:
CAS_60559-98-0 | NSC_43345 | P1075
Type:
Small organic molecule
Emp. Form.:
C12H17N5
Mol. Mass.:
231.2969
SMILES:
CCC(C)(C)N=C(NC#N)Nc1cccnc1 |w:5.4|
Structure:
