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Target
Glycogen synthase kinase-3 beta
Ligand
BDBM97721
Substrate
n/a
Meas. Tech.
Biochemical Assay
Temperature
303.15±n/a K
IC50
8±0.0 nM
Comments
extracted
Citation
 Siegel, S; Wilmen, A; Röhrig, S; Svenstrup, N; Gnoth, MJ; Heitmeier, S; Rester, U; Tersteegen, A; Gerisch, M Imidazo-, pyrazolopyrazines and imidazotriazines and their use US Patent  US8476267 Publication Date 7/2/2013 
Target
Name:
Glycogen synthase kinase-3 beta
Synonyms:
GSK-3 beta | GSK-3, beta | GSK3B | GSK3B_HUMAN | Glycogen synthase kinase 3 beta (GSK3B) | Glycogen synthase kinase 3-beta (GSK3B) | Glycogen synthase kinase-3 beta (GSK-3B) | Glycogen synthase kinase-3 beta (GSK3 Beta) | Glycogen synthase kinase-3 beta (GSK3B) | Glycogen synthase kinase-3B (GSK-3B) | Glycogen synthase kinase-3beta (GSK3B) | Serine/threonine-protein kinase GSK3B
Type:
Enzyme
Mol. Mass.:
46756.38
Organism:
Homo sapiens (Human)
Description:
P49841
Residue:
420
Sequence:
MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST
  
Inhibitor
Name:
BDBM97721
Synonyms:
US8476267, 17
Type:
Small organic molecule
Emp. Form.:
C25H25Cl2N7O3S
Mol. Mass.:
574.482
SMILES:
CCOC(=O)c1cc2c(nc(cn2n1)-c1ccc(Cl)cc1Cl)N1CCCC(C1)Nc1nc(N)c(s1)C(C)=O
Structure:
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