Reaction Details Report a problem with these data
Target
Histone deacetylase 8
Ligand
BDBM152727
Substrate
n/a
Meas. Tech.
HDAC8 Fluorimetric Assay
pH
8.2±n/a
IC50
1.4e+4± 1e+3 nM
Comments
extracted
Citation
 Decroos, C; Christianson, DW Design, Synthesis, and Evaluation of Polyamine Deacetylase Inhibitors, and High-Resolution Crystal Structures of Their Complexes with Acetylpolyamine Amidohydrolase. Biochemistry 54:4692-703 (2015) [PubMed]  Article 
Target
Name:
Histone deacetylase 8
Synonyms:
HD8 | HDAC8 | HDAC8_HUMAN | HDACL1 | Histone deacetylase 8 (HDAC-8) | Human HDAC8
Type:
Enzyme
Mol. Mass.:
41749.60
Organism:
Homo sapiens (Human)
Description:
Q9BY41
Residue:
377
Sequence:
MEEPEEPADSGQSLVPVYIYSPEYVSMCDSLAKIPKRASMVHSLIEAYALHKQMRIVKPKVASMEEMATFHTDAYLQHLQKVSQEGDDDHPDSIEYGLGYDCPATEGIFDYAAAIGGATITAAQCLIDGMCKVAINWSGGWHHAKKDEASGFCYLNDAVLGILRLRRKFERILYVDLDLHHGDGVEDAFSFTSKVMTVSLHKFSPGFFPGTGDVSDVGLGKGRYYSVNVPIQDGIQDEKYYQICESVLKEVYQAFNPKAVVLQLGADTIAGDPMCSFNMTPVGIGKCLKYILQWQLATLILGGGGYNLANTARCWTYLTGVILGKTLSSEIPDHEFFTAYGPDYVLEITPSCRPDRNEPHRIQQILNYIKGNLKHVV
  
Inhibitor
Name:
BDBM152727
Synonyms:
(3-azaniumylpropyl)[5-(hydroxycarbamoyl)pentyl]azanium (3)
Type:
Small organic molecule
Emp. Form.:
C9H23N3O2
Mol. Mass.:
205.2967
SMILES:
[NH3+]CCC[NH2+]CCCCCC(=O)NO
Structure:
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