Reaction Details Report a problem with these data
Target
Tyrosine-protein kinase BTK [393-659]
Ligand
BDBM287439
Substrate
n/a
Meas. Tech.
Time-Resolved Fluorescence Resonance Energy Transfer (TR-FRET)
pH
6.5±n/a
Temperature
298.15±n/a K
IC50
<100±n/a nM
Comments
extracted
Citation
Bonafoux, D; Davis, HM; Frank, KE; Friedman, MM; Herold, JM; Hoemann, MZ; Huntley, R; Osuma, A; Sheppard, G; Somal, GK; Van Camp, J; Van Epps, SA; Vasudevan, A; Wallace, GA; Wang, L; Wang, L; Wang, Z; Wilson, NS; Xu, X Primary carboxamides as BTK inhibitors US Patent US9567339 Publication Date 2/14/2017
More Info.:
Target
Name:
Tyrosine-protein kinase BTK [393-659]
Synonyms:
AGMX1 | ATK | BPK | BTK | BTK_HUMAN | Tyrosine-protein kinase BTK
Type:
Enzyme Catalytic Domain
Mol. Mass.:
31165.48
Organism:
Human
Description:
aa 393-659
Residue:
267
Sequence:
GSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEES