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Target
G-protein coupled estrogen receptor 1
Ligand
BDBM288684
Substrate
n/a
Meas. Tech.
Biological Assay
IC50
0.640±n/a nM
Citation
 Yu, S; Yang, F; Chen, L; Yan, J; Zhang, X; Xie, Z; Chen, L; He, M Piperidine derivative and preparation method and pharmaceutical use thereof US Patent  US10087191 Publication Date 10/2/2018 
Target
Name:
G-protein coupled estrogen receptor 1
Synonyms:
CEPR | CMKRL2 | DRY12 | G-protein coupled estrogen receptor 1 | G-protein-coupled receptor (GPR30 ) | GPER | GPER1 | GPER1_HUMAN | GPR30
Type:
PROTEIN
Mol. Mass.:
42259.21
Organism:
Human
Description:
ChEMBL_982507
Residue:
375
Sequence:
MDVTSQARGVGLEMYPGTAQPAAPNTTSPELNLSHPLLGTALANGTGELSEHQQYVIGLFLSCLYTIFLFPIGFVGNILILVVNISFREKMTIPDLYFINLAVADLILVADSLIEVFNLHERYYDIAVLCTFMSLFLQVNMYSSVFFLTWMSFDRYIALARAMRCSLFRTKHHARLSCGLIWMASVSATLVPFTAVHLQHTDEACFCFADVREVQWLEVTLGFIVPFAIIGLCYSLIVRVLVRAHRHRGLRPRRQKALRMILAVVLVFFVCWLPENVFISVHLLQRTQPGAAPCKQSFRHAHPLTGHIVNLAAFSNSCLNPLIYSFLGETFRDKLRLYIEQKTNLPALNRFCHAALKAVIPDSTEQSDVRFSSAV
  
Inhibitor
Name:
BDBM288684
Synonyms:
(E)-3-(4-((6R,8R/6S,8S)-7-isobutyl-8-methyl-6,7,8,9-tetrahydro-3H-pyrazolo[4,3-f]isoquinolin-6-yl)phenyl)acrylic acid | US10087191, Example 102
Type:
Small organic molecule
Emp. Form.:
C24H27N3O2
Mol. Mass.:
389.4901
SMILES:
CC(C)CN1C(C)Cc2c(ccc3[nH]ncc23)C1c1ccc(\C=C\C(O)=O)cc1
Structure:
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