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Target
Protein mono-ADP-ribosyltransferase PARP14 [1611-1801]
Ligand
BDBM434138
Substrate
n/a
Meas. Tech.
Enzymatic Inhibition Assay
IC50
<1000±n/a nM
Citation
 Schenkel, LB; Vasbinder, MM; Kuntz, KW; Swinger, KK Quinazolinones as PARP14 inhibitors US Patent  US10562891 Publication Date 2/18/2020 
Target
Name:
Protein mono-ADP-ribosyltransferase PARP14 [1611-1801]
Synonyms:
BAL2 | KIAA1268 | PAR14_HUMAN | PARP14 | Protein mono-ADP-ribosyltransferase PARP14 (aa 1611-1801)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
21749.94
Organism:
Homo sapiens (Human)
Description:
aa 1611-1801
Residue:
190
Sequence:
DMKQQNFCVVELLPSDPEYNTVASKFNQTCSHFRIEKIERIQNPDLWNSYQAKKKTMDAKNGQTMNEKQLFHGTDAGSVPHVNRNGFNRSYAGKNAVAYGKGTYFAVNANYSANDTYSRPDANGRKHVYYVRVLTGIYTHGNHSLIVPPSKNPQNPTDLYDTVTDNVHHPSLFVAFYDYQAYPEYLITFR
  
Inhibitor
Name:
BDBM434138
Synonyms:
US10562891, Example 60 | US11008308, Example 61
Type:
Small organic molecule
Emp. Form.:
C17H19F3N2O2S
Mol. Mass.:
372.405
SMILES:
Cc1ccc(c2c1nc(CS[C@@H]1CC[C@H](O)CC1)[nH]c2=O)C(F)(F)F |r,wU:11.11,14.15,(-5.33,-9.52,;-5.33,-7.98,;-6.67,-7.21,;-6.67,-5.67,;-5.33,-4.9,;-4,-5.67,;-4,-7.21,;-2.67,-7.98,;-1.33,-7.21,;,-7.98,;1.33,-7.21,;2.67,-7.98,;2.67,-9.52,;4,-10.29,;5.33,-9.52,;6.67,-10.29,;5.33,-7.98,;4,-7.21,;-1.33,-5.67,;-2.67,-4.9,;-2.67,-3.36,;-5.33,-3.36,;-6.67,-2.59,;-4,-2.59,;-5.33,-1.82,)|
Structure:
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