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Target
Protein mono-ADP-ribosyltransferase TIPARP
Ligand
BDBM431549
Substrate
n/a
Meas. Tech.
Enzymatic Assay
IC50
<100±n/a nM
Citation
 Vasbinder, MM; Schenkel, LB; Swinger, KK; Kuntz, KW Pyridazinones as PARP7 inhibitors US Patent  US10870641 Publication Date 12/22/2020 
Target
Name:
Protein mono-ADP-ribosyltransferase TIPARP
Synonyms:
ADP-ribosyltransferase diphtheria toxin-like 14 | ARTD14 | PARP-7 | PARP7 | PARPT_HUMAN | Poly [ADP-ribose] polymerase 7 | TCDD-inducible poly [ADP-ribose] polymerase | TIPARP
Type:
Protein
Mol. Mass.:
76228.44
Organism:
Human
Description:
Q7Z3E1
Residue:
657
Sequence:
MEMETTEPEPDCVVQPPSPPDDFSCQMRLSEKITPLKTCFKKKDQKRLGTGTLRSLRPILNTLLESGSLDGVFRSRNQSTDENSLHEPMMKKAMEINSSCPPAENNMSVLIPDRTNVGDQIPEAHPSTEAPERVVPIQDHSFPSETLSGTVADSTPAHFQTDLLHPVSSDVPTSPDCLDKVIDYVPGIFQENSFTIQYILDTSDKLSTELFQDKSEEASLDLVFELVNQLQYHTHQENGIEICMDFLQGTCIYGRDCLKHHTVLPYHWQIKRTTTQKWQSVFNDSQEHLERFYCNPENDRMRMKYGGQEFWADLNAMNVYETTEFDQLRRLSTPPSSNVNSIYHTVWKFFCRDHFGWREYPESVIRLIEEANSRGLKEVRFMMWNNHYILHNSFFRREIKRRPLFRSCFILLPYLQTLGGVPTQAPPPLEATSSSQIICPDGVTSANFYPETWVYMHPSQDFIQVPVSAEDKSYRIIYNLFHKTVPEFKYRILQILRVQNQFLWEKYKRKKEYMNRKMFGRDRIINERHLFHGTSQDVVDGICKHNFDPRVCGKHATMFGQGSYFAKKASYSHNFSKKSSKGVHFMFLAKVLTGRYTMGSHGMRRPPPVNPGSVTSDLYDSCVDNFFEPQIFVIFNDDQSYPYFVIQYEEVSNTVSI
  
Inhibitor
Name:
BDBM431549
Synonyms:
US10550105, Example 494 | US10870641, Example 494 | US11014913, Example 494
Type:
Small organic molecule
Emp. Form.:
C30H24F3N7O3
Mol. Mass.:
587.5519
SMILES:
FC(F)(F)c1c(cn[nH]c1=O)N1Cc2cccc(Oc3ccc(cc3)C(=O)N3CCN(CC3)c3ccc(cn3)C#N)c2C1
Structure:
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