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Target
Glycogen synthase kinase-3 beta
Ligand
BDBM484631
Substrate
n/a
Meas. Tech.
Kinase Assay
EC50
788±n/a nM
Citation
 Kc, SK; Mak, CC; Mittapalli, GK; Hofilena, BJ; Eastman, BW; Cao, J; Chiruta, C; Bollu, V 5-heteroaryl substituted indazole-3-carboxamides and preparation and use thereof US Patent  US10934297 Publication Date 3/2/2021 
Target
Name:
Glycogen synthase kinase-3 beta
Synonyms:
GSK-3 beta | GSK-3, beta | GSK3B | GSK3B_HUMAN | Glycogen synthase kinase 3 beta (GSK3B) | Glycogen synthase kinase 3-beta (GSK3B) | Glycogen synthase kinase-3 beta (GSK-3B) | Glycogen synthase kinase-3 beta (GSK3 Beta) | Glycogen synthase kinase-3 beta (GSK3B) | Glycogen synthase kinase-3B (GSK-3B) | Glycogen synthase kinase-3beta (GSK3B) | Serine/threonine-protein kinase GSK3B
Type:
Enzyme
Mol. Mass.:
46756.38
Organism:
Homo sapiens (Human)
Description:
P49841
Residue:
420
Sequence:
MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST
  
Inhibitor
Name:
BDBM484631
Synonyms:
US10934297, Compound 25 | US11713320, Compound 25
Type:
Small organic molecule
Emp. Form.:
C25H33FN6O
Mol. Mass.:
452.5675
SMILES:
CC(C)(C)n1cc(cn1)-c1ccc2[nH]nc(C(=O)N[C@H]3CC[C@H](CN4CC(F)C4)CC3)c2c1 |r,wU:22.23,wD:19.19,(-6.11,1.5,;-7.2,.41,;-8.69,.8,;-7.6,1.89,;-6.8,-1.08,;-5.34,-1.56,;-5.34,-3.1,;-6.8,-3.57,;-7.71,-2.33,;-4,-3.87,;-4,-5.41,;-2.67,-6.18,;-1.34,-5.41,;.13,-5.88,;1.03,-4.64,;.13,-3.39,;.53,-1.9,;-.56,-.81,;2.01,-1.51,;2.41,-.02,;3.9,.38,;4.3,1.87,;3.21,2.96,;3.61,4.44,;5.1,4.84,;6.43,4.07,;7.2,5.41,;8.69,5.81,;5.87,6.18,;1.72,2.56,;1.32,1.07,;-1.34,-3.87,;-2.67,-3.1,)|
Structure:
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