Reaction Details Report a problem with these data
Target
Glycogen synthase kinase-3 beta
Ligand
BDBM484632
Substrate
n/a
Meas. Tech.
Kinase Assay
EC50
34.0±n/a nM
Citation
 Kc, SK; Mak, CC; Mittapalli, GK; Hofilena, BJ; Eastman, BW; Cao, J; Chiruta, C; Bollu, V 5-heteroaryl substituted indazole-3-carboxamides and preparation and use thereof US Patent  US10934297 Publication Date 3/2/2021 
Target
Name:
Glycogen synthase kinase-3 beta
Synonyms:
GSK-3 beta | GSK-3, beta | GSK3B | GSK3B_HUMAN | Glycogen synthase kinase 3 beta (GSK3B) | Glycogen synthase kinase 3-beta (GSK3B) | Glycogen synthase kinase-3 beta (GSK-3B) | Glycogen synthase kinase-3 beta (GSK3 Beta) | Glycogen synthase kinase-3 beta (GSK3B) | Glycogen synthase kinase-3B (GSK-3B) | Glycogen synthase kinase-3beta (GSK3B) | Serine/threonine-protein kinase GSK3B
Type:
Enzyme
Mol. Mass.:
46756.38
Organism:
Homo sapiens (Human)
Description:
P49841
Residue:
420
Sequence:
MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST
  
Inhibitor
Name:
BDBM484632
Synonyms:
US10934297, Compound 26 | US11713320, Compound 26
Type:
Small organic molecule
Emp. Form.:
C24H29FN6O
Mol. Mass.:
436.5251
SMILES:
FC1CN(C[C@H]2CC[C@@H](CC2)NC(=O)c2n[nH]c3ccc(cc23)-c2cnn(c2)C2CC2)C1 |r,wU:5.4,wD:8.11,(8.49,5.81,;7,5.41,;6.23,4.07,;4.9,4.84,;3.41,4.44,;3.01,2.96,;4.1,1.87,;3.7,.38,;2.21,-.02,;1.13,1.07,;1.52,2.56,;1.82,-1.51,;.33,-1.9,;-.76,-.81,;-.07,-3.39,;.83,-4.64,;-.07,-5.88,;-1.54,-5.41,;-2.87,-6.18,;-4.2,-5.41,;-4.2,-3.87,;-2.87,-3.1,;-1.54,-3.87,;-5.54,-3.1,;-7,-3.57,;-7.91,-2.33,;-7,-1.08,;-5.54,-1.56,;-7.4,.41,;-7,1.89,;-8.49,1.5,;5.67,6.18,)|
Structure:
Search PDB for entries with ligand similarity: