Reaction Details Report a problem with these data
Target
PAS domain-containing serine/threonine-protein kinase [879-1323]
Ligand
BDBM487201
Substrate
n/a
Meas. Tech.
Kinase Luminescence Assay
IC50
>10000±n/a nM
Citation
 McCall, JM; Kelly, RC; Romero, DL Heterocyclic compounds for the inhibition of pask US Patent  US10953012 Publication Date 3/23/2021 
Target
Name:
PAS domain-containing serine/threonine-protein kinase [879-1323]
Synonyms:
KIAA0135 | PAS domain-containing serine/threonine-protein kinase (PASK) (879-1323) | PASK | PASK_HUMAN
Type:
Enzyme Catalytic Domain
Mol. Mass.:
49711.83
Organism:
Homo sapiens (Human)
Description:
aa 879-1323
Residue:
445
Sequence:
MRGAAGLQREIQEGAYSGSCYHRDGLRLSIQFEVRRVELQGPTPLFCCWLVKDLLHSQRDSAARTRLFLASLPGSTHSTAAELTGPSLVEVLRARPWFEEPPKAVELEGLAACEGEYSQKYSTMSPLGSGAFGFVWTAVDKEKNKEVVVKFIKKEKVLEDCWIEDPKLGKVTLEIAILSRVEHANIIKVLDIFENQGFFQLVMEKHGSGLDLFAFIDRHPRLDEPLASYIFRQLVSAVGYLRLKDIIHRDIKDENIVIAEDFTIKLIDFGSAAYLERGKLFYTFCGTIEYCAPEVLMGNPYRGPELEMWSLGVTLYTLVFEENPFCELEETVEAAIHPPYLVSKELMSLVSGLLQPVPERRTTLEKLVTDPWVTQPVNLADYTWEEVFRVNKPESGVLSAASLEMGNRSLSDVAQAQELCGGPVPGEAPNGQGCLHPGDPRLLTS
  
Inhibitor
Name:
BDBM487201
Synonyms:
3-(4-Chlorophenyl)-2-methyl-6,7-dihydro-4H-cyclopenta[d]pyrazolo[1,5-a]pyrimidin-8(5H)-one | US10953012, Example 27
Type:
Small organic molecule
Emp. Form.:
C16H14ClN3O
Mol. Mass.:
299.755
SMILES:
Cc1nn2c([nH]c3CCCc3c2=O)c1-c1ccc(Cl)cc1
Structure:
Search PDB for entries with ligand similarity: