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Found 1135 with Last Name = 'mccall' and Initial = 'jm'
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM29568(CHEMBL2 | PRAZOSIN | PRAZOSIN HYDROCHLORIDE | [3H]...)
Affinity DataKi:  0.160nMAssay Description:Compound was tested for the inhibition of [3H]prazosin binding Alpha-1 adrenergic receptor of crude rat brain membrane.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50016897(2-(2,6-dichloroanilino)-1,3-diazacyclopentene-(2) ...)
Affinity DataKi:  1.70nMAssay Description:Compound was tested for the inhibition of [3H]clonidine binding Alpha-2 adrenergic receptor of crude rat brain membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50223655(CHEMBL160763)
Affinity DataKi:  4nMAssay Description:Compound was tested for the inhibition of [3H]prazosin binding Alpha-2 adrenergic receptor of crude rat brain membrane.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50026847(1-[2-(6,7-Dimethoxy-isochroman-1-yl)-ethyl]-4-(4-f...)
Affinity DataKi:  4nMAssay Description:Compound was tested for the inhibition of [3H]prazosin binding alpha-1-adrenergic receptor of crude rat brain membrane.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM31046(3-[4,5-dihydro-1H-imidazol-2-ylmethyl-(4-methylphe...)
Affinity DataKi:  9.30nMAssay Description:Compound was tested for the inhibition of [3H]clonidine binding Alpha-2 adrenergic receptor of crude rat brain membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM31046(3-[4,5-dihydro-1H-imidazol-2-ylmethyl-(4-methylphe...)
Affinity DataKi:  9.80nMAssay Description:Compound was tested for the inhibition of [3H]prazosin binding Alpha-1 adrenergic receptor of crude rat brain membrane.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50026847(1-[2-(6,7-Dimethoxy-isochroman-1-yl)-ethyl]-4-(4-f...)
Affinity DataKi:  62nMAssay Description:Compound was tested for the inhibition of [3H]clonidine binding Alpha-2 adrenergic receptor of crude rat brain membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50223655(CHEMBL160763)
Affinity DataKi:  307nMAssay Description:Compound was tested for the inhibition of [3H]clonidine binding Alpha-2 adrenergic receptor of crude rat brain membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50016897(2-(2,6-dichloroanilino)-1,3-diazacyclopentene-(2) ...)
Affinity DataKi:  528nMAssay Description:Compound was tested for the inhibition of [3H]prazosin binding Alpha-1 adrenergic receptor of crude rat brain membrane.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM29568(CHEMBL2 | PRAZOSIN | PRAZOSIN HYDROCHLORIDE | [3H]...)
Affinity DataKi:  1.80E+3nMAssay Description:Compound was tested for the inhibition of [3H]clonidine binding Alpha-2 adrenergic receptor of crude rat brain membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingolipid delta(4)-desaturase DES1(Homo sapiens (Human))
Centaurus Therapeutics

US Patent
LigandPNGBDBM523251(N-(5-hydroxy- pyridin-2-yl)-7- methyloctan- amide ...)
Affinity DataIC50:  1nMAssay Description:Jurkat clone E6-1 cells were grown and then seeded at 106 cells/mL in a 96-well plate (400 μL in each well. The cells were administered 100 _...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSphingolipid delta(4)-desaturase DES1(Homo sapiens (Human))
Centaurus Therapeutics

US Patent
LigandPNGBDBM523252((1r,4r)-4-(4- chlorophenyl)- N-(5-hydroxy- pyridin...)
Affinity DataIC50:  1nMAssay Description:Jurkat clone E6-1 cells were grown and then seeded at 106 cells/mL in a 96-well plate (400 μL in each well. The cells were administered 100 _...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSphingolipid delta(4)-desaturase DES1(Homo sapiens (Human))
Centaurus Therapeutics

US Patent
LigandPNGBDBM523268(N-(5-hydroxypyridin-2-yl)-1-[4-(trifluoromethyl)ph...)
Affinity DataIC50:  2nMAssay Description:Jurkat clone E6-1 cells were grown and then seeded at 106 cells/mL in a 96-well plate (400 μL in each well. The cells were administered 100 _...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSphingolipid delta(4)-desaturase DES1(Homo sapiens (Human))
Centaurus Therapeutics

US Patent
LigandPNGBDBM523246(N-(5-hydroxy- pyridin-2-yl)- 4'-chloro- biphenyl-4...)
Affinity DataIC50:  3nMAssay Description:Jurkat clone E6-1 cells were grown and then seeded at 106 cells/mL in a 96-well plate (400 μL in each well. The cells were administered 100 _...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSphingolipid delta(4)-desaturase DES1(Homo sapiens (Human))
Centaurus Therapeutics

US Patent
LigandPNGBDBM523270(2-[1-(5-chloropyridin-2-yl)piperidin-4-yl]-N-(5-hy...)
Affinity DataIC50:  3.90nMAssay Description:Jurkat clone E6-1 cells were grown and then seeded at 106 cells/mL in a 96-well plate (400 μL in each well. The cells were administered 100 _...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSphingolipid delta(4)-desaturase DES1(Homo sapiens (Human))
Centaurus Therapeutics

US Patent
LigandPNGBDBM523243(N-(5-hydroxy- pyridin-2-yl)- 4-cyclohexyl- benzami...)
Affinity DataIC50:  4nMAssay Description:Jurkat clone E6-1 cells were grown and then seeded at 106 cells/mL in a 96-well plate (400 μL in each well. The cells were administered 100 _...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSphingolipid delta(4)-desaturase DES1(Homo sapiens (Human))
Centaurus Therapeutics

US Patent
LigandPNGBDBM523254(4-(tert-butyl)- N-(5-hydroxy- pyridin-2-yl)- benza...)
Affinity DataIC50:  4nMAssay Description:Jurkat clone E6-1 cells were grown and then seeded at 106 cells/mL in a 96-well plate (400 μL in each well. The cells were administered 100 _...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSphingolipid delta(4)-desaturase DES1(Homo sapiens (Human))
Centaurus Therapeutics

US Patent
LigandPNGBDBM523249((1r,4r)-N-(5- hydroxy- pyridin-2-yl)- 4-phenyl- cy...)
Affinity DataIC50:  5nMAssay Description:Jurkat clone E6-1 cells were grown and then seeded at 106 cells/mL in a 96-well plate (400 μL in each well. The cells were administered 100 _...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSphingolipid delta(4)-desaturase DES1(Homo sapiens (Human))
Centaurus Therapeutics

US Patent
LigandPNGBDBM523266(2-[1-(4-chlorophenyl)piperidin-4-yl]-N-(5-hydroxyp...)
Affinity DataIC50:  5nMAssay Description:Jurkat clone E6-1 cells were grown and then seeded at 106 cells/mL in a 96-well plate (400 μL in each well. The cells were administered 100 _...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSphingolipid delta(4)-desaturase DES1(Homo sapiens (Human))
Centaurus Therapeutics

US Patent
LigandPNGBDBM523245(N-(5-hydroxy- pyridin-2-yl)- 4'-cyano- biphenyl-4-...)
Affinity DataIC50:  5nMAssay Description:Jurkat clone E6-1 cells were grown and then seeded at 106 cells/mL in a 96-well plate (400 μL in each well. The cells were administered 100 _...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSphingolipid delta(4)-desaturase DES1(Homo sapiens (Human))
Centaurus Therapeutics

US Patent
LigandPNGBDBM523250(N-(5-hydroxy- pyridin-2-yl)- octanamide | US111352...)
Affinity DataIC50:  6nMAssay Description:Jurkat clone E6-1 cells were grown and then seeded at 106 cells/mL in a 96-well plate (400 μL in each well. The cells were administered 100 _...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails US Patent
TargetSphingolipid delta(4)-desaturase DES1(Homo sapiens (Human))
Centaurus Therapeutics

US Patent
LigandPNGBDBM523236(N-(5-hydroxy- pyridin-2-yl)- (1,1'- biphenyl)-4- c...)
Affinity DataIC50:  10nMAssay Description:Jurkat clone E6-1 cells were grown and then seeded at 106 cells/mL in a 96-well plate (400 μL in each well. The cells were administered 100 _...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSphingolipid delta(4)-desaturase DES1(Homo sapiens (Human))
Centaurus Therapeutics

US Patent
LigandPNGBDBM523269(1-(4-fluorophenyl)-N-(5-hydroxypyridin-2-yl)piperi...)
Affinity DataIC50:  11nMAssay Description:Jurkat clone E6-1 cells were grown and then seeded at 106 cells/mL in a 96-well plate (400 μL in each well. The cells were administered 100 _...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSphingolipid delta(4)-desaturase DES1(Homo sapiens (Human))
Centaurus Therapeutics

US Patent
LigandPNGBDBM523264(2-[1-(4-fluorophenyl) piperidin-4-yl]-N-(5-hydroxy...)
Affinity DataIC50:  13nMAssay Description:Jurkat clone E6-1 cells were grown and then seeded at 106 cells/mL in a 96-well plate (400 μL in each well. The cells were administered 100 _...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSphingolipid delta(4)-desaturase DES1(Homo sapiens (Human))
Centaurus Therapeutics

US Patent
LigandPNGBDBM523244(N-(5-hydroxy- pyridin-2-yl)- 4'-methoxy- biphenyl-...)
Affinity DataIC50:  14nMAssay Description:Jurkat clone E6-1 cells were grown and then seeded at 106 cells/mL in a 96-well plate (400 μL in each well. The cells were administered 100 _...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSphingolipid delta(4)-desaturase DES1(Homo sapiens (Human))
Centaurus Therapeutics

US Patent
LigandPNGBDBM523248(N-(5-hydroxy- pyridin-2-yl)- 4-isopropyl- benzamid...)
Affinity DataIC50:  16nMAssay Description:Jurkat clone E6-1 cells were grown and then seeded at 106 cells/mL in a 96-well plate (400 μL in each well. The cells were administered 100 _...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSphingolipid delta(4)-desaturase DES1(Homo sapiens (Human))
Centaurus Therapeutics

US Patent
LigandPNGBDBM523256(2'-chloro-N- (5-hydroxy- pyridin-2-yl)- [1,1'- bip...)
Affinity DataIC50:  19nMAssay Description:Jurkat clone E6-1 cells were grown and then seeded at 106 cells/mL in a 96-well plate (400 μL in each well. The cells were administered 100 _...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSphingolipid delta(4)-desaturase DES1(Homo sapiens (Human))
Centaurus Therapeutics

US Patent
LigandPNGBDBM523255(N-(5-hydroxy- pyridin-2-yl)- 5-isopropoxy- pentana...)
Affinity DataIC50:  21nMAssay Description:Jurkat clone E6-1 cells were grown and then seeded at 106 cells/mL in a 96-well plate (400 μL in each well. The cells were administered 100 _...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSphingolipid delta(4)-desaturase DES1(Homo sapiens (Human))
Centaurus Therapeutics

US Patent
LigandPNGBDBM523257((1r,4r)-N-(5- hydroxypyridin- 2-yl)-4-iso- propoxy...)
Affinity DataIC50:  21nMAssay Description:Jurkat clone E6-1 cells were grown and then seeded at 106 cells/mL in a 96-well plate (400 μL in each well. The cells were administered 100 _...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSphingolipid delta(4)-desaturase DES1(Homo sapiens (Human))
Centaurus Therapeutics

US Patent
LigandPNGBDBM523261(N-(5-hydroxy- pyridin-2-yl)- 4-(1,1,1- trifluoro- ...)
Affinity DataIC50:  23nMAssay Description:Jurkat clone E6-1 cells were grown and then seeded at 106 cells/mL in a 96-well plate (400 μL in each well. The cells were administered 100 _...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSphingolipid delta(4)-desaturase DES1(Homo sapiens (Human))
Centaurus Therapeutics

US Patent
LigandPNGBDBM523262(N-(5-hydroxypyridin-2-yl)-2-[4-[4-(trifluoromethyl...)
Affinity DataIC50:  50nMAssay Description:Jurkat clone E6-1 cells were grown and then seeded at 106 cells/mL in a 96-well plate (400 μL in each well. The cells were administered 100 _...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSphingolipid delta(4)-desaturase DES1(Homo sapiens (Human))
Centaurus Therapeutics

US Patent
LigandPNGBDBM523232(N-(4-hydroxy- phcnyl)-[1,1'- biphenyl]-4- carboxam...)
Affinity DataIC50:  50nMAssay Description:Jurkat clone E6-1 cells were grown and then seeded at 106 cells/mL in a 96-well plate (400 μL in each well. The cells were administered 100 _...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSphingolipid delta(4)-desaturase DES1(Homo sapiens (Human))
Centaurus Therapeutics

US Patent
LigandPNGBDBM523235(N-(5-hydroxy- pyridin-2-yl)- cinnamide | US1113520...)
Affinity DataIC50:  60nMAssay Description:Jurkat clone E6-1 cells were grown and then seeded at 106 cells/mL in a 96-well plate (400 μL in each well. The cells were administered 100 _...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSphingolipid delta(4)-desaturase DES1(Homo sapiens (Human))
Centaurus Therapeutics

US Patent
LigandPNGBDBM523260(N-(5-hydroxy- pyridin-2-yl)- 4-(trifluoro- methyl)...)
Affinity DataIC50:  63nMAssay Description:Jurkat clone E6-1 cells were grown and then seeded at 106 cells/mL in a 96-well plate (400 μL in each well. The cells were administered 100 _...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSphingolipid delta(4)-desaturase DES1(Homo sapiens (Human))
Centaurus Therapeutics

US Patent
LigandPNGBDBM523267(2-[4-(4-chlorophenyl)piperazin-1-yl]-N-(5-hydroxyp...)
Affinity DataIC50:  66nMAssay Description:Jurkat clone E6-1 cells were grown and then seeded at 106 cells/mL in a 96-well plate (400 μL in each well. The cells were administered 100 _...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSphingolipid delta(4)-desaturase DES1(Homo sapiens (Human))
Centaurus Therapeutics

US Patent
LigandPNGBDBM523258((1s,4s)-N-(5- hydroxypyridin- 2-yl)-4-iso- propoxy...)
Affinity DataIC50:  88nMAssay Description:Jurkat clone E6-1 cells were grown and then seeded at 106 cells/mL in a 96-well plate (400 μL in each well. The cells were administered 100 _...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSphingolipid delta(4)-desaturase DES1(Homo sapiens (Human))
Centaurus Therapeutics

US Patent
LigandPNGBDBM523241(N-(4-hydroxy- phenyl)-4- cyclohexyl- benzamide | U...)
Affinity DataIC50:  90nMAssay Description:Jurkat clone E6-1 cells were grown and then seeded at 106 cells/mL in a 96-well plate (400 μL in each well. The cells were administered 100 _...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSphingolipid delta(4)-desaturase DES1(Homo sapiens (Human))
Centaurus Therapeutics

US Patent
LigandPNGBDBM523259(4-ethyl-N-(5- hydroxy- pyridin-2-yl)- benzamide | ...)
Affinity DataIC50:  130nMAssay Description:Jurkat clone E6-1 cells were grown and then seeded at 106 cells/mL in a 96-well plate (400 μL in each well. The cells were administered 100 _...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSphingolipid delta(4)-desaturase DES1(Homo sapiens (Human))
Centaurus Therapeutics

US Patent
LigandPNGBDBM523253(N-(5-hydroxy- pyridin-2-yl)- 4-(pyridin-3- yl)benz...)
Affinity DataIC50:  130nMAssay Description:Jurkat clone E6-1 cells were grown and then seeded at 106 cells/mL in a 96-well plate (400 μL in each well. The cells were administered 100 _...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSphingolipid delta(4)-desaturase DES1(Homo sapiens (Human))
Centaurus Therapeutics

US Patent
LigandPNGBDBM523265(2-[4-(4-fluorophenyl)piperazin-1-yl]-N-(5-hydroxyp...)
Affinity DataIC50:  140nMAssay Description:Jurkat clone E6-1 cells were grown and then seeded at 106 cells/mL in a 96-well plate (400 μL in each well. The cells were administered 100 _...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSphingolipid delta(4)-desaturase DES1(Homo sapiens (Human))
Centaurus Therapeutics

US Patent
LigandPNGBDBM523234(N-(5-hydroxy- pyridin-2-yl)- 2-naphth- amide | US1...)
Affinity DataIC50:  180nMAssay Description:Jurkat clone E6-1 cells were grown and then seeded at 106 cells/mL in a 96-well plate (400 μL in each well. The cells were administered 100 _...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSphingolipid delta(4)-desaturase DES1(Homo sapiens (Human))
Centaurus Therapeutics

US Patent
LigandPNGBDBM523237((trans)-N-(5- hydroxy- pyridin-2-yl)- 2-phenyl- cy...)
Affinity DataIC50:  230nMAssay Description:Jurkat clone E6-1 cells were grown and then seeded at 106 cells/mL in a 96-well plate (400 μL in each well. The cells were administered 100 _...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSphingolipid delta(4)-desaturase DES1(Homo sapiens (Human))
Centaurus Therapeutics

US Patent
LigandPNGBDBM523247(N-(5-hydroxy- pyridin-2-yl)- 4-methoxy- benzamide ...)
Affinity DataIC50:  240nMAssay Description:Jurkat clone E6-1 cells were grown and then seeded at 106 cells/mL in a 96-well plate (400 μL in each well. The cells were administered 100 _...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSphingolipid delta(4)-desaturase DES1(Homo sapiens (Human))
Centaurus Therapeutics

US Patent
LigandPNGBDBM523263(1-(4-fluorophenyl)-N-(5-hydroxypyridin-2-yl)piperi...)
Affinity DataIC50:  250nMAssay Description:Jurkat clone E6-1 cells were grown and then seeded at 106 cells/mL in a 96-well plate (400 μL in each well. The cells were administered 100 _...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSphingolipid delta(4)-desaturase DES1(Homo sapiens (Human))
Centaurus Therapeutics

US Patent
LigandPNGBDBM50429763(CHEMBL229844 | N-(4-Hydroxyphenyl)Cinnamamide | US...)
Affinity DataIC50:  440nMAssay Description:Jurkat clone E6-1 cells were grown and then seeded at 106 cells/mL in a 96-well plate (400 μL in each well. The cells were administered 100 _...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSphingolipid delta(4)-desaturase DES1(Homo sapiens (Human))
Centaurus Therapeutics

US Patent
LigandPNGBDBM523233((trans)-N-(4- hydroxyphenyl)- 2-phenyl- cyclopropa...)
Affinity DataIC50:  590nMAssay Description:Jurkat clone E6-1 cells were grown and then seeded at 106 cells/mL in a 96-well plate (400 μL in each well. The cells were administered 100 _...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
Imago Biosciences

US Patent
LigandPNGBDBM425103(N-((S)-5-((1R,2S)-2-(4- fluorophenyl)cyclopropylam...)
Affinity DataIC50:  800nMAssay Description:The KDM1A demethylase enzyme activity can obtained from mammalian cells or tissues expressing KDM1A from an endogenous or recombinant gene and purifi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
Imago Biosciences

US Patent
LigandPNGBDBM425103(N-((S)-5-((1R,2S)-2-(4- fluorophenyl)cyclopropylam...)
Affinity DataIC50:  800nMAssay Description:Briefly, bulk histones, histone peptides or nucleosomes are incubated with purified human recombinant KDM1A, in the histone demethylase activity (HDM...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSphingolipid delta(4)-desaturase DES1(Homo sapiens (Human))
Centaurus Therapeutics

US Patent
LigandPNGBDBM523229(N-(4-hydroxy- phenyl)-2- naphthamide | US11135207,...)
Affinity DataIC50:  840nMAssay Description:Jurkat clone E6-1 cells were grown and then seeded at 106 cells/mL in a 96-well plate (400 μL in each well. The cells were administered 100 _...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPAS domain-containing serine/threonine-protein kinase(Homo sapiens (Human))
Bioenergenix

US Patent
LigandPNGBDBM463470(2-Phenyl-3-(4-(4-(trifluoromethyl)phenyl)piperidin...)
Affinity DataIC50: <1.00E+3nMAssay Description:Purified PASK (UniProt # Q96RG2; human recombinant N-terminal GST tagged construct, residues 879-1323) from insect cells (final concentration 5 nM) i...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
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