Reaction Details Report a problem with these data
Target
Sphingolipid delta(4)-desaturase DES1
Ligand
BDBM523262
Substrate
n/a
Meas. Tech.
Des1 Activity Assays
IC50
50.0±n/a nM
Citation
 Romero, DL; McCall, JM; Blitzer, J Inhibitors of dihydroceramide desaturase for treating disease US Patent  US11135207 Publication Date 10/5/2021 
Target
Name:
Sphingolipid delta(4)-desaturase DES1
Synonyms:
Cell migration-inducing gene 15 protein | DEGS1 | DEGS1_HUMAN | DES1 | Degenerative spermatocyte homolog 1 | MLD | Membrane lipid desaturase
Type:
PROTEIN
Mol. Mass.:
37872.63
Organism:
Homo sapiens (Human)
Description:
ChEMBL_816893
Residue:
323
Sequence:
MGSRVSREDFEWVYTDQPHADRRREILAKYPEIKSLMKPDPNLIWIIIMMVLTQLGAFYIVKDLDWKWVIFGAYAFGSCINHSMTLAIHEIAHNAAFGNCKAMWNRWFGMFANLPIGIPYSISFKRYHMDHHRYLGADGVDVDIPTDFEGWFFCTAFRKFIWVILQPLFYAFRPLFINPKPITYLEVINTVAQVTFDILIYYFLGIKSLVYMLAASLLGLGLHPISGHFIAEHYMFLKGHETYSYYGPLNLLTFNVGYHNEHHDFPNIPGKSLPLVRKIAAEYYDNLPHYNSWIKVLYDFVMDDTISPYSRMKRHQKGEMVLE
  
Inhibitor
Name:
BDBM523262
Synonyms:
N-(5-hydroxypyridin-2-yl)-2-[4-[4-(trifluoromethyl)phenyl]piperazin-1-yl]acetamide | US11135207, Example 47
Type:
Small organic molecule
Emp. Form.:
C18H19F3N4O2
Mol. Mass.:
380.3643
SMILES:
Oc1ccc(NC(=O)CN2CCN(CC2)c2ccc(cc2)C(F)(F)F)nc1
Structure:
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