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Target
PAS domain-containing serine/threonine-protein kinase [879-1323]
Ligand
BDBM487204
Substrate
n/a
Meas. Tech.
Kinase Luminescence Assay
IC50
>10000±n/a nM
Citation
 McCall, JM; Kelly, RC; Romero, DL Heterocyclic compounds for the inhibition of pask US Patent  US10953012 Publication Date 3/23/2021 
Target
Name:
PAS domain-containing serine/threonine-protein kinase [879-1323]
Synonyms:
KIAA0135 | PAS domain-containing serine/threonine-protein kinase (PASK) (879-1323) | PASK | PASK_HUMAN
Type:
Enzyme Catalytic Domain
Mol. Mass.:
49711.83
Organism:
Homo sapiens (Human)
Description:
aa 879-1323
Residue:
445
Sequence:
MRGAAGLQREIQEGAYSGSCYHRDGLRLSIQFEVRRVELQGPTPLFCCWLVKDLLHSQRDSAARTRLFLASLPGSTHSTAAELTGPSLVEVLRARPWFEEPPKAVELEGLAACEGEYSQKYSTMSPLGSGAFGFVWTAVDKEKNKEVVVKFIKKEKVLEDCWIEDPKLGKVTLEIAILSRVEHANIIKVLDIFENQGFFQLVMEKHGSGLDLFAFIDRHPRLDEPLASYIFRQLVSAVGYLRLKDIIHRDIKDENIVIAEDFTIKLIDFGSAAYLERGKLFYTFCGTIEYCAPEVLMGNPYRGPELEMWSLGVTLYTLVFEENPFCELEETVEAAIHPPYLVSKELMSLVSGLLQPVPERRTTLEKLVTDPWVTQPVNLADYTWEEVFRVNKPESGVLSAASLEMGNRSLSDVAQAQELCGGPVPGEAPNGQGCLHPGDPRLLTS
  
Inhibitor
Name:
BDBM487204
Synonyms:
5-Isopropyl-2-(4-methoxy-phenyl)-3-phenyl-4H-pyrazolo[1,5-a]pyrimidin-7-one | US10953012, Example 30
Type:
Small organic molecule
Emp. Form.:
C22H21N3O2
Mol. Mass.:
359.421
SMILES:
COc1ccc(cc1)-c1nn2c([nH]c(cc2=O)C(C)C)c1-c1ccccc1
Structure:
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