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Target
Tyrosine-protein phosphatase non-receptor type 11 [E76K]
Ligand
BDBM488491
Substrate
n/a
Meas. Tech.
Enzymatic Assay
IC50
48.0±n/a nM
Citation
 Jones, P; Cross, J; Burke, J; Mcafoos, T; Kang, Z Substituted heterocyclic inhibitors of PTPN11 US Patent  US10954243 Publication Date 3/23/2021 
Target
Name:
Tyrosine-protein phosphatase non-receptor type 11 [E76K]
Synonyms:
PTN11_HUMAN | PTP2C | PTPN11 | Protein-tyrosine phosphatase 1D | SHPTP2 | Tyrosine-protein phosphatase non-receptor type 11 | Tyrosine-protein phosphatase non-receptor type 11 (PTPN11)(E76K)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
68019.14
Organism:
Human
Description:
Q06124[E76K]
Residue:
593
Sequence:
MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR
  
Inhibitor
Name:
BDBM488491
Synonyms:
(6-((3S,4S)-4- amino-3-methyl-2- oxa-8- azaspiro[4.5]decan- 8-yl)-3-(3-chloro-2- (oxetan-3- yloxy)pyridin-4-yl)- 1H-pyrazolo[3,4- b]pyrazin-5- yl)methanol | US10954243, Example 22
Type:
Small organic molecule
Emp. Form.:
C23H28ClN7O4
Mol. Mass.:
501.966
SMILES:
C[C@@H]1OCC2(CCN(CC2)c2nc3[nH]nc(-c4ccnc(OC5COC5)c4Cl)c3nc2CO)[C@@H]1N |r|
Structure:
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