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Target
Prostacyclin receptor
Ligand
BDBM357272
Substrate
n/a
Meas. Tech.
Homogeneous Time-Resolved Fluorescence (HTRF) Assay
EC50
2.00±n/a nM
Citation
 Tran, T; Ibarra, JB; Shin, Y; Ullman, B; Zou, N; Zeng, X Pyrazolyl substituted carbonic acid derivatives as modulators of the prostacyclin (PGI2) receptor useful for the treatment of disorders related thereto US Patent  US11098034 Publication Date 8/24/2021 
Target
Name:
Prostacyclin receptor
Synonyms:
PGI receptor | PI2R_HUMAN | PRIPR | PTGIR | Prostacyclin (IP) Receptor | Prostacyclin receptor | Prostaglandin I | Prostaglandin I2 | Prostaglandin I2 receptor | Prostanoid IP receptor
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
40968.22
Organism:
Human
Description:
The membranes prepared from human platelet were used in binding assay.
Residue:
386
Sequence:
MADSCRNLTYVRGSVGPATSTLMFVAGVVGNGLALGILSARRPARPSAFAVLVTGLAATDLLGTSFLSPAVFVAYARNSSLLGLARGGPALCDAFAFAMTFFGLASMLILFAMAVERCLALSHPYLYAQLDGPRCARLALPAIYAFCVLFCALPLLGLGQHQQYCPGSWCFLRMRWAQPGGAAFSLAYAGLVALLVAAIFLCNGSVTLSLCRMYRQQKRHQGSLGPRPRTGEDEVDHLILLALMTVVMAVCSLPLTIRCFTQAVAPDSSSEMGDLLAFRFYAFNPILDPWVFILFRKAVFQRLKLWVCCLCLGPAHGDSQTPLSQLASGRRDPRAPSAPVGKEGSCVPLSAWGEGQVEPLPPTQQSSGSAVGTSSKAEASVACSLC
  
Inhibitor
Name:
BDBM357272
Synonyms:
2-(((1s,4s)-4-((5-(2- hydroxyethylthio)-4-(3- methoxyphenyl)-3-phenyl- 1H-pyrazol-1- yl)methyl)cyclohexyl) methoxy)acetic acid | US10214518, Compound 198 | US11098034, Compound 198
Type:
Small organic molecule
Emp. Form.:
C28H34N2O5S
Mol. Mass.:
510.645
SMILES:
COc1cccc(c1)-c1c(SCCO)n(C[C@@H]2CC[C@H](COCC(O)=O)CC2)nc1-c1ccccc1 |r,wU:16.16,19.20,(-10.55,-.25,;-9.06,-.65,;-7.97,.44,;-8.37,1.93,;-7.28,3.02,;-5.8,2.62,;-5.4,1.13,;-6.49,.04,;-3.91,.73,;-2.83,1.83,;-3.23,3.32,;-2.14,4.41,;-.65,4.01,;.44,5.1,;-1.45,1.14,;-.12,1.91,;1.21,1.14,;1.21,-.4,;2.55,-1.17,;3.88,-.4,;5.22,-1.17,;6.55,-.4,;7.88,-1.17,;9.22,-.4,;10.55,-1.17,;9.22,1.14,;3.88,1.14,;2.55,1.91,;-1.68,-.38,;-3.2,-.63,;-3.6,-2.12,;-5.09,-2.52,;-5.48,-4.01,;-4.4,-5.1,;-2.91,-4.7,;-2.51,-3.21,)|
Structure:
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