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Target
cAMP-specific 3',5'-cyclic phosphodiesterase 4A [2-825]
Ligand
BDBM577155
Substrate
n/a
Meas. Tech.
Scintillation Proximity Assay
IC50
11.8±n/a nM
Citation
 Chappie, TA; Patel, NC; Verhoest, PR; Helal, CJ; Sciabola, S; LaChapelle, EA; Wager, TT; Chandrasekaran, RY Tricyclic compounds and their use as phosphodiesterase inhibitors US Patent  US11472805 Publication Date 10/18/2022 
Target
Name:
cAMP-specific 3',5'-cyclic phosphodiesterase 4A [2-825]
Synonyms:
DPDE2 | PDE4A | PDE4A_HUMAN | cAMP-specific 3',5'-cyclic phosphodiesterase (PDE4A3) (2-825)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
92170.87
Organism:
Homo sapiens (Human)
Description:
aa 2-825
Residue:
824
Sequence:
EPPTVPSERSLSLSLPGPREGQATLKPPPQHLWRQPRTPIRIQQRGYSDSAERAERERQPHRPIERADAMDTSDRPGLRTTRMSWPSSFHGTGTGSGGAGGGSSRRFEAENGPTPSPGRSPLDSQASPGLVLHAGAATSQRRESFLYRSDSDYDMSPKTMSRNSSVTSEAHAEDLIVTPFAQVLASLRSVRSNFSLLTNVPVPSNKRSPLGGPTPVCKATLSEETCQQLARETLEELDWCLEQLETMQTYRSVSEMASHKFKRMLNRELTHLSEMSRSGNQVSEYISTTFLDKQNEVEIPSPTMKEREKQQAPRPRPSQPPPPPVPHLQPMSQITGLKKLMHSNSLNNSNIPRFGVKTDQEELLAQELENLNKWGLNIFCVSDYAGGRSLTCIMYMIFQERDLLKKFRIPVDTMVTYMLTLEDHYHADVAYHNSLHAADVLQSTHVLLATPALDAVFTDLEILAALFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEDNCDIFQNLSKRQRQSLRKMVIDMVLATDMSKHMTLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLRNMVHCADLSNPTKPLELYRQWTDRIMAEFFQQGDRERERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETWADLVHPDAQEILDTLEDNRDWYYSAIRQSPSPPPEEESRGPGHPPLPDKFQFELTLEEEEEEEISMAQIPCTAQEALTAQGLSGVEEALDATIAWEASPAQESLEVMAQEASLEAELEAVYLTQQAQSTGSAPVAPDEFSSREEFVVAVSHSSPSALALQSPLLPAWR
  
Inhibitor
Name:
BDBM577155
Synonyms:
3-(8-Cyclopropyl-9-oxo-6,7,8,9-tetrahydropyrido[2',3':4,5]pyrrolo[1,2-a]pyrazin-10-yl)-4-methylbenzonitrile | US11472805, Example 60
Type:
Small organic molecule
Emp. Form.:
C21H18N4O
Mol. Mass.:
342.3938
SMILES:
Cc1ccc(cc1-c1c2C(=O)N(CCn2c2cccnc12)C1CC1)C#N |(-3,2.12,;-1.5,2.44,;-1.02,3.91,;.48,4.23,;1.57,3.09,;1.04,1.62,;-.47,1.3,;-.94,-.17,;-.04,-1.41,;1.49,-1.57,;2.4,-.33,;2.12,-2.98,;1.21,-4.23,;-.32,-4.07,;-.94,-2.66,;-2.41,-2.18,;-3.74,-2.95,;-5.08,-2.18,;-5.08,-.64,;-3.74,.13,;-2.41,-.64,;3.65,-3.14,;4.87,-4.08,;5.08,-2.56,;3.07,3.41,;4.58,3.73,)|
Structure:
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