Reaction Details Report a problem with these data
Target
cAMP-specific 3',5'-cyclic phosphodiesterase 4A [2-825]
Ligand
BDBM577166
Substrate
n/a
Meas. Tech.
Scintillation Proximity Assay
IC50
2.80±n/a nM
Citation
 Chappie, TA; Patel, NC; Verhoest, PR; Helal, CJ; Sciabola, S; LaChapelle, EA; Wager, TT; Chandrasekaran, RY Tricyclic compounds and their use as phosphodiesterase inhibitors US Patent  US11472805 Publication Date 10/18/2022 
Target
Name:
cAMP-specific 3',5'-cyclic phosphodiesterase 4A [2-825]
Synonyms:
DPDE2 | PDE4A | PDE4A_HUMAN | cAMP-specific 3',5'-cyclic phosphodiesterase (PDE4A3) (2-825)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
92170.87
Organism:
Human
Description:
aa 2-825
Residue:
824
Sequence:
EPPTVPSERSLSLSLPGPREGQATLKPPPQHLWRQPRTPIRIQQRGYSDSAERAERERQPHRPIERADAMDTSDRPGLRTTRMSWPSSFHGTGTGSGGAGGGSSRRFEAENGPTPSPGRSPLDSQASPGLVLHAGAATSQRRESFLYRSDSDYDMSPKTMSRNSSVTSEAHAEDLIVTPFAQVLASLRSVRSNFSLLTNVPVPSNKRSPLGGPTPVCKATLSEETCQQLARETLEELDWCLEQLETMQTYRSVSEMASHKFKRMLNRELTHLSEMSRSGNQVSEYISTTFLDKQNEVEIPSPTMKEREKQQAPRPRPSQPPPPPVPHLQPMSQITGLKKLMHSNSLNNSNIPRFGVKTDQEELLAQELENLNKWGLNIFCVSDYAGGRSLTCIMYMIFQERDLLKKFRIPVDTMVTYMLTLEDHYHADVAYHNSLHAADVLQSTHVLLATPALDAVFTDLEILAALFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEDNCDIFQNLSKRQRQSLRKMVIDMVLATDMSKHMTLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLRNMVHCADLSNPTKPLELYRQWTDRIMAEFFQQGDRERERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETWADLVHPDAQEILDTLEDNRDWYYSAIRQSPSPPPEEESRGPGHPPLPDKFQFELTLEEEEEEEISMAQIPCTAQEALTAQGLSGVEEALDATIAWEASPAQESLEVMAQEASLEAELEAVYLTQQAQSTGSAPVAPDEFSSREEFVVAVSHSSPSALALQSPLLPAWR
  
Inhibitor
Name:
BDBM577166
Synonyms:
4-(8-Cyclopropyl-9-oxo-8,9-dihydropyrido[2',3':4,5]pyrrolo[1,2-a]pyrazin-10-yl)benzonitrile | US11472805, Example 70
Type:
Small organic molecule
Emp. Form.:
C20H14N4O
Mol. Mass.:
326.3514
SMILES:
O=c1n(ccn2c3cccnc3c(-c3ccc(cc3)C#N)c12)C1CC1
Structure:
Search PDB for entries with ligand similarity: