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Target
Dimer of Gag-Pol polyprotein [489-587,Q496K]
Ligand
BDBM9141
Substrate
HIV Protease Peptide Substrate
Meas. Tech.
Protease Inhibition Assay
pH
5.5±n/a
Temperature
303.15±n/a K
IC50
0.07±n/a nM
Citation
Zhang, F; Chapman, KT; Schleif, WA; Olsen, DB; Stahlhut, M; Rutkowski, CA; Kuo, LC; Jin, L; Lin, JH; Emini, EA; Tata, JR The design, synthesis and evaluation of novel HIV-1 protease inhibitors with high potency against PI-resistant viral strains. Bioorg Med Chem Lett 13:2573-6 (2003) [PubMed] Article
More Info.:
Target
Name:
Dimer of Gag-Pol polyprotein [489-587,Q496K]
Synonyms:
HIV-1 Protease | HIV-1 Protease NL4-3 | HIV-1 protease wild-type
Type:
Protein Complex
Mol. Mass.:
n/a
Description:
n/a
Components:
This complex has 2 components.
Component 1
Name:
Gag-Pol polyprotein [489-587,Q496K]
Synonyms:
HIV-1 Protease Chain A | HIV-1 Protease NL4-3 | POL_HV1N5 | gag-pol
Type:
Enzyme Subunit
Mol. Mass.:
10823.26
Organism:
Human immunodeficiency virus type 1
Description:
P12497[489-587,Q496K]
Residue:
99
Sequence:
PQITLWKRPLVTIKIGGQLKEALLDTGADDTVLEEMNLPGRWKPKMIGGIGGFIKVRQYDQILIEICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF
Component 2
Name:
Gag-Pol polyprotein [489-587,Q496K]
Synonyms:
HIV-1 Protease Chain A | HIV-1 Protease NL4-3 | POL_HV1N5 | gag-pol
Type:
Enzyme Subunit
Mol. Mass.:
10823.26
Organism:
Human immunodeficiency virus type 1
Description:
P12497[489-587,Q496K]
Residue:
99
Sequence:
PQITLWKRPLVTIKIGGQLKEALLDTGADDTVLEEMNLPGRWKPKMIGGIGGFIKVRQYDQILIEICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF
Inhibitor
Name:
BDBM9141
Synonyms:
(2S)-1-[(2S,4R)-4-benzyl-2-hydroxy-4-{[(3S,4S)-3-hydroxy-3,4-dihydro-2H-1-benzopyran-4-yl]carbamoyl}butyl]-4-(2-{furo[3,2-c]pyridin-2-yl}propan-2-yl)-N-(2,2,2-trifluoroethyl)piperazine-2-carboxamide | CHEMBL79236 | P3 pyridylfuran analog 2
Type:
Small organic molecule
Emp. Form.:
C38H44F3N5O6
Mol. Mass.:
723.7811
SMILES:
CC(C)(N1CCN(C[C@@H](O)C[C@@H](Cc2ccccc2)C(=O)N[C@@H]2[C@H](O)COc3ccccc23)[C@@H](C1)C(=O)NCC(F)(F)F)c1cc2cnccc2o1 |r|
Substrate
Name:
HIV Protease Peptide Substrate
Synonyms:
HIV Protease Substrate
Type:
Peptide
Mol. Mass.:
2715.95
Organism:
n/a
Description:
n/a
Residue:
25
Sequence:
VSQNETANAPHTHYLALANINEPIV