Reaction Details Report a problem with these data
Target
Tyrosine-protein phosphatase non-receptor type 6 [205-595]
Ligand
BDBM24533
Substrate
BDBM13432
Meas. Tech.
Phosphatase Activity Assay
pH
7±n/a
Temperature
295.15±n/a K
IC50
15400±2100 nM
Citation
Lawrence, HR; Pireddu, R; Chen, L; Luo, Y; Sung, SS; Szymanski, AM; Yip, ML; Guida, WC; Sebti, SM; Wu, J; Lawrence, NJ Inhibitors of Src homology-2 domain containing protein tyrosine phosphatase-2 (Shp2) based on oxindole scaffolds. J Med Chem 51:4948-56 (2008) [PubMed] Article
Target
Name:
Tyrosine-protein phosphatase non-receptor type 6 [205-595]
Synonyms:
HCP | Hematopoietic cell protein-tyrosine phosphatase | PTN6_HUMAN | PTP-1C | PTP1C | PTPN6 | Protein-Tyrosine Phosphatase SHP-1 | Protein-tyrosine phosphatase 1C | SH-PTP1 | Tyrosine-protein phosphatase non-receptor type 6
Type:
Protein phosphatase
Mol. Mass.:
44886.26
Organism:
Human
Description:
Human recombinant GST-fusion SHP-1 (205-595).
Residue:
391
Sequence:
AFVYLRQPYYATRVNAADIENRVLELNKKQESEDTAKAGFWEEFESLQKQEVKNLHQRLEGQRPENKGKNRYKNILPFDHSRVILQGRDSNIPGSDYINANYIKNQLLGPDENAKTYIASQGCLEATVNDFWQMAWQENSRVIVMTTREVEKGRNKCVPYWPEVGMQRAYGPYSVTNCGEHDTTEYKLRTLQVSPLDNGDLIREIWHYQYLSWPDHGVPSEPGGVLSFLDQINQRQESLPHAGPIIVHCSAGIGRTGTIIVIDMLMENISTKGLDCDIDIQKTIQMVRAQRSGMVQTEAQYKFIYVAIAQFIETTKKKLEVLQSQKGQESEYGNITYPPAMKNAHAKASRTSSKHKEDVYENLHTKNKREEKVKKQRSADKEKSKGSLKRK
Inhibitor
Name:
BDBM24533
Synonyms:
(3Z)-3-[2-(2-carboxyphenyl)hydrazin-1-ylidene]-2-oxo-2,3-dihydro-1H-indole-5-carboxylic acid | Oxindole scaffold, 14a
Type:
Small organic molecule
Emp. Form.:
C16H11N3O5
Mol. Mass.:
325.2756
SMILES:
OC(=O)c1ccc2NC(=O)C(=NNc3ccccc3C(O)=O)c2c1 |w:11.11|