Reaction Details Report a problem with these data
Target
Tyrosine-protein phosphatase non-receptor type 6 [205-595]
Ligand
BDBM24545
Substrate
BDBM13432
Meas. Tech.
Phosphatase Activity Assay
IC50
60800±n/a nM
Citation
Lawrence, HR; Pireddu, R; Chen, L; Luo, Y; Sung, SS; Szymanski, AM; Yip, ML; Guida, WC; Sebti, SM; Wu, J; Lawrence, NJ Inhibitors of Src homology-2 domain containing protein tyrosine phosphatase-2 (Shp2) based on oxindole scaffolds. J Med Chem 51:4948-56 (2008) [PubMed] Article
More Info.:
Target
Name:
Tyrosine-protein phosphatase non-receptor type 6 [205-595]
Synonyms:
HCP | Hematopoietic cell protein-tyrosine phosphatase | PTN6_HUMAN | PTP-1C | PTP1C | PTPN6 | Protein-Tyrosine Phosphatase SHP-1 | Protein-tyrosine phosphatase 1C | SH-PTP1 | Tyrosine-protein phosphatase non-receptor type 6
Type:
Protein phosphatase
Mol. Mass.:
44886.26
Organism:
Human
Description:
Human recombinant GST-fusion SHP-1 (205-595).
Residue:
391
Sequence:
AFVYLRQPYYATRVNAADIENRVLELNKKQESEDTAKAGFWEEFESLQKQEVKNLHQRLEGQRPENKGKNRYKNILPFDHSRVILQGRDSNIPGSDYINANYIKNQLLGPDENAKTYIASQGCLEATVNDFWQMAWQENSRVIVMTTREVEKGRNKCVPYWPEVGMQRAYGPYSVTNCGEHDTTEYKLRTLQVSPLDNGDLIREIWHYQYLSWPDHGVPSEPGGVLSFLDQINQRQESLPHAGPIIVHCSAGIGRTGTIIVIDMLMENISTKGLDCDIDIQKTIQMVRAQRSGMVQTEAQYKFIYVAIAQFIETTKKKLEVLQSQKGQESEYGNITYPPAMKNAHAKASRTSSKHKEDVYENLHTKNKREEKVKKQRSADKEKSKGSLKRK
Inhibitor
Name:
BDBM24545
Synonyms:
4-{2-[(3Z)-5-{[(2-chlorophenyl)methyl]sulfamoyl}-2-oxo-2,3-dihydro-1H-indol-3-ylidene]hydrazin-1-yl}benzoic acid | Oxindole scaffold, 10j
Type:
Small organic molecule
Emp. Form.:
C22H17ClN4O5S
Mol. Mass.:
484.912
SMILES:
OC(=O)c1ccc(NN=C2C(=O)Nc3ccc(cc23)S(=O)(=O)NCc2ccccc2Cl)cc1 |w:8.7|