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Target
Neuronal acetylcholine receptor subunit alpha-7
Ligand
BDBM50259921
Substrate
n/a
Meas. Tech.
ChEBML_1691998
EC50
35±n/a nM
Citation
 Hill, MD; Fang, H; Digavalli, SV; Healy, FL; Gallagher, L; Post-Munson, D; Chen, P; Natale, J; Benitex, Y; Morgan, D; Lodge, N; Bristow, L; Macor, JE; Olson, RE Development of spiroguanidine-derived?7 neuronal nicotinic receptor partial agonists. Bioorg Med Chem Lett 27:578-581 (2017) [PubMed]  Article 
Target
Name:
Neuronal acetylcholine receptor subunit alpha-7
Synonyms:
ACHA7_HUMAN | CHRNA7 | Cholinergic, Nicotinic Alpha7 | NACHRA7 | Neuronal acetylcholine receptor protein alpha-7 subunit | Neuronal acetylcholine receptor subunit alpha-7 (nAChR-alpha 7) | Nicotinic acetylcholine receptor alpha-7 (alpha7 nAChR)
Type:
n/a
Mol. Mass.:
56448.33
Organism:
Human
Description:
CHRNA7 (NACHRA7)
Residue:
502
Sequence:
MRCSPGGVWLALAASLLHVSLQGEFQRKLYKELVKNYNPLERPVANDSQPLTVYFSLSLLQIMDVDEKNQVLTTNIWLQMSWTDHYLQWNVSEYPGVKTVRFPDGQIWKPDILLYNSADERFDATFHTNVLVNSSGHCQYLPPGIFKSSCYIDVRWFPFDVQHCKLKFGSWSYGGWSLDLQMQEADISGYIPNGEWDLVGIPGKRSERFYECCKEPYPDVTFTVTMRRRTLYYGLNLLIPCVLISALALLVFLLPADSGEKISLGITVLLSLTVFMLLVAEIMPATSDSVPLIAQYFASTMIIVGLSVVVTVIVLQYHHHDPDGGKMPKWTRVILLNWCAWFLRMKRPGEDKVRPACQHKQRRCSLASVEMSAVAPPPASNGNLLYIGFRGLDGVHCVPTPDSGVVCGRMACSPTHDEHLLHGGQPPEGDPDLAKILEEVRYIANRFRCQDESEAVCSEWKFAACVVDRLCLMAFSVFTIICTIGILMSAPNFVEAVSKDFA
  
Inhibitor
Name:
BDBM50259921
Synonyms:
CHEMBL4086223
Type:
Small organic molecule
Emp. Form.:
C17H21N5O
Mol. Mass.:
311.3815
SMILES:
Cc1ccc2nc(NC3=NCC4(CN5CCC4CC5)N3)oc2c1 |t:8,THB:19:11:14.15:17.18,(15.03,-19.9,;13.7,-20.67,;13.7,-22.22,;12.37,-22.99,;11.04,-22.22,;9.57,-22.69,;8.67,-21.46,;7.12,-21.45,;6.35,-22.79,;6.98,-24.19,;5.83,-25.22,;4.5,-24.45,;4.29,-25.84,;2.37,-25.03,;.97,-25.96,;1.32,-24.56,;3.02,-23.81,;2.95,-22.17,;2.37,-23.56,;4.82,-22.95,;9.57,-20.2,;11.04,-20.68,;12.36,-19.91,)|
Structure:
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