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Target
Arachidonate 5-lipoxygenase-activating protein
Ligand
BDBM50261947
Substrate
n/a
Meas. Tech.
ChEMBL_1696510 (CHEMBL4047400)
IC50
16±n/a nM
Citation
 Bartolozzi, A; Abeywardane, A; Bosanac, T; Broadwater, JA; Chen, Z; Hutzler, JM; Huber, JD; Nemoto, P; Olague, A; Riether, D; Simpson, T; Takahashi, H; Wu, L; Zhang, Y; Zindell, RM Discovery and optimization of oxadiazole-based FLAP inhibitors. Bioorg Med Chem Lett 27:4652-4659 (2017) [PubMed]  Article 
Target
Name:
Arachidonate 5-lipoxygenase-activating protein
Synonyms:
5-lipoxygenase activating protein | 5-lipoxygenase-activating protein (FLAP) | 5-lipoxygenase/FLAP | AL5AP_HUMAN | ALOX5AP | FLAP | MK-886-binding protein
Type:
Enzyme
Mol. Mass.:
18159.90
Organism:
Homo sapiens (Human)
Description:
P20292
Residue:
161
Sequence:
MDQETVGNVVLLAIVTLISVVQNGFFAHKVEHESRTQNGRSFQRTGTLAFERVYTANQNCVDAYPTFLAVLWSAGLLCSQVPAAFAGLMYLFVRQKYFVGYLGERTQSTPGYIFGKRIILFLFLMSVAGIFNYYLIFFFGSDFENYIKTISTTISPLLLIP
  
Inhibitor
Name:
BDBM50261947
Synonyms:
CHEMBL4079550
Type:
Small organic molecule
Emp. Form.:
C20H22N8O
Mol. Mass.:
390.4417
SMILES:
CC(C)[C@@](C)(c1noc(n1)-c1cnn(C)c1)c1ccc(nc1)-c1cnc(N)nc1 |r|
Structure:
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