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Target
Prostaglandin D2 receptor 2
Ligand
BDBM50458669
Substrate
n/a
Meas. Tech.
ChEMBL_1764479 (CHEMBL4199726)
IC50
43±n/a nM
Citation
 Huang, X; Brubaker, J; Zhou, W; Biju, PJ; Xiao, L; Shao, N; Huang, Y; Dong, L; Liu, Z; Bitar, R; Buevich, A; Jung, J; Peterson, SL; Butcher, JW; Close, J; Martinez, M; MacCoss, RN; Zhang, H; Crawford, S; McCormick, KD; Aslanian, R; Nargund, R; Correll, C; Gervais, F; Qiu, H; Yang, X; Garlisi, C; Rindgen, D; Maloney, KM; Siliphaivanh, P; Palani, A Discovery of MK-8318, a Potent and Selective CRTh2 Receptor Antagonist for the Treatment of Asthma. ACS Med Chem Lett 9:679-684 (2018) [PubMed]  Article 
Target
Name:
Prostaglandin D2 receptor 2
Synonyms:
CD_antigen=CD294 | CRTH2 | Chemoattractant Receptor-homologous molecule expressed on T-helper type 2 cells (CRTH2) | Chemoattractant receptor-homologous molecule expressed on Th2 cells | Chemoattractant receptor-homologous molecule expressed on Th2 cells (CRTH2) | DL1R | G protein-coupled receptor 44 | G-protein coupled receptor 44 | GPR44 | PD2R2_HUMAN | PTGDR2 | Prostaglandin D2 | Prostaglandin D2 receptor 2 | Prostaglandin D2 receptor 2 (PGD2)
Type:
Enzyme
Mol. Mass.:
43295.45
Organism:
Human
Description:
Q9Y5Y4
Residue:
395
Sequence:
MSANATLKPLCPILEQMSRLQSHSNTSIRYIDHAAVLLHGLASLLGLVENGVILFVVGCRMRQTVVTTWVLHLALSDLLASASLPFFTYFLAVGHSWELGTTFCKLHSSIFFLNMFASGFLLSAISLDRCLQVVRPVWAQNHRTVAAAHKVCLVLWALAVLNTVPYFVFRDTISRLDGRIMCYYNVLLLNPGPDRDATCNSRQVALAVSKFLLAFLVPLAIIASSHAAVSLRLQHRGRRRPGRFVRLVAAVVAAFALCWGPYHVFSLLEARAHANPGLRPLVWRGLPFVTSLAFFNSVANPVLYVLTCPDMLRKLRRSLRTVLESVLVDDSELGGAGSSRRRRTSSTARSASPLALCSRPEEPRGPARLLGWLLGSCAASPQTGPLNRALSSTSS
  
Inhibitor
Name:
BDBM50458669
Synonyms:
CHEMBL4215049
Type:
Small organic molecule
Emp. Form.:
C26H25F3N2O5
Mol. Mass.:
502.4823
SMILES:
[H][C@@]12CC[C@]1([H])N(C(=O)c1cccc(OC(F)(F)F)c1)c1ccccc1[C@@H]2N(C1CC1)C(=O)CCC(O)=O |r|
Structure:
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