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Target
Muscarinic acetylcholine receptor M1
Ligand
BDBM50464175
Substrate
n/a
Meas. Tech.
ChEMBL_1780191 (CHEMBL4237183)
EC50
14±n/a nM
Citation
 Engers, JL; Childress, ES; Long, MF; Capstick, RA; Luscombe, VB; Cho, HP; Dickerson, JW; Rook, JM; Blobaum, AL; Niswender, CM; Engers, DW; Conn, PJ; Lindsley, CW VU6007477, a Novel M ACS Med Chem Lett 9:917-922 (2018) [PubMed]  Article 
Target
Name:
Muscarinic acetylcholine receptor M1
Synonyms:
ACM1_RAT | Cholinergic, muscarinic M1 | Chrm-1 | Chrm1 | cholinergic receptor, muscarinic 1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
51390.46
Organism:
RAT
Description:
P08482
Residue:
460
Sequence:
MNTSVPPAVSPNITVLAPGKGPWQVAFIGITTGLLSLATVTGNLLVLISFKVNTELKTVNNYFLLSLACADLIIGTFSMNLYTTYLLMGHWALGTLACDLWLALDYVASNASVMNLLLISFDRYFSVTRPLSYRAKRTPRRAALMIGLAWLVSFVLWAPAILFWQYLVGERTVLAGQCYIQFLSQPIITFGTAMAAFYLPVTVMCTLYWRIYRETENRARELAALQGSETPGKGGGSSSSSERSQPGAEGSPESPPGRCCRCCRAPRLLQAYSWKEEEEEDEGSMESLTSSEGEEPGSEVVIKMPMVDSEAQAPTKQPPKSSPNTVKRPTKKGRDRGGKGQKPRGKEQLAKRKTFSLVKEKKAARTLSAILLAFILTWTPYNIMVLVSTFCKDCVPETLWELGYWLCYVNSTVNPMCYALCNKAFRDTFRLLLLCRWDKRRWRKIPKRPGSVHRTPSRQC
  
Inhibitor
Name:
BDBM50464175
Synonyms:
CHEMBL4247625
Type:
Small organic molecule
Emp. Form.:
C24H26N6O3
Mol. Mass.:
446.5016
SMILES:
Cn1ccc(n1)-c1ccc(Cc2cc(nc3n(C)ccc23)C(=O)N[C@@H]2CCOC[C@H]2O)cn1 |r|
Structure:
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