Reaction Details Report a problem with these data
Target
Somatostatin receptor type 5
Ligand
BDBM123216
Substrate
n/a
Meas. Tech.
ChEMBL_1798205 (CHEMBL4270322)
IC50
1.5±n/a nM
Citation
 Liu, W; Hussain, Z; Zang, Y; Sweis, RF; Romero, FA; Finke, PE; Moningka, R; Bao, J; Plotkin, MA; Shang, J; Dingley, KH; Salituro, G; Murphy, BA; Howard, AD; Ujjainwalla, F; Wood, HB; Duffy, JL Optimization of Preclinical Metabolism for Somatostatin Receptor Subtype 5-Selective Antagonists. ACS Med Chem Lett 9:1088-1093 (2018) [PubMed]  Article 
Target
Name:
Somatostatin receptor type 5
Synonyms:
SOMATOSTATIN SST5 | SS-5-R | SS5-R | SS5R | SSR5_HUMAN | SSTR5 | Somatostatin receptor type 5 (SSTR5)
Type:
Enzyme
Mol. Mass.:
39218.02
Organism:
Homo sapiens (Human)
Description:
P35346
Residue:
364
Sequence:
MEPLFPASTPSWNASSPGAASGGGDNRTLVGPAPSAGARAVLVPVLYLLVCAAGLGGNTLVIYVVLRFAKMKTVTNIYILNLAVADVLYMLGLPFLATQNAASFWPFGPVLCRLVMTLDGVNQFTSVFCLTVMSVDRYLAVVHPLSSARWRRPRVAKLASAAAWVLSLCMSLPLLVFADVQEGGTCNASWPEPVGLWGAVFIIYTAVLGFFAPLLVICLCYLLIVVKVRAAGVRVGCVRRRSERKVTRMVLVVVLVFAGCWLPFFTVNIVNLAVALPQEPASAGLYFFVVILSYANSCANPVLYGFLSDNFRQSFQKVLCLRKGSGAKDADATEPRPDRIRQQQEATPPAHRAAANGLMQTSKL
  
Inhibitor
Name:
BDBM123216
Synonyms:
US8742110, 3-1
Type:
Small organic molecule
Emp. Form.:
C31H33FN2O6
Mol. Mass.:
548.6019
SMILES:
CCOc1cc(CN2CCC3(CN(C(=O)O3)c3ccc(cc3)C(O)=O)CC2)cc(OCC)c1-c1ccc(F)cc1
Structure:
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