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Target
Integrase
Ligand
BDBM50480407
Substrate
n/a
Meas. Tech.
ChEMBL_571770 (CHEMBL1033786)
IC50
250±n/a nM
Citation
 Sato, M; Kawakami, H; Motomura, T; Aramaki, H; Matsuda, T; Yamashita, M; Ito, Y; Matsuzaki, Y; Yamataka, K; Ikeda, S; Shinkai, H Quinolone carboxylic acids as a novel monoketo acid class of human immunodeficiency virus type 1 integrase inhibitors. J Med Chem 52:4869-82 (2009) [PubMed]  Article 
Target
Name:
Integrase
Synonyms:
pol
Type:
PROTEIN
Mol. Mass.:
32203.43
Organism:
Human immunodeficiency virus 1
Description:
ChEMBL_106649
Residue:
288
Sequence:
FLDGIDKAQEEHEKYHSNWRAMASDFNLPPVVAKEIVASCDKCQLKGEAMHGQVDCSPGIWQLDCTHLEGKVILVAVHVASGYIEAEVIPAETGQETAYFLLKLAGRWPVKTVHTDNGSNFTSTTVKAACWWAGIKQEFGIPYNPQSQGVIESMNKELKKIIGQVRDQAEHLKTAVQMAVFIHNFKRKGGIGGYSAGERIVDIIATDIQTKELQKQITKIQNFRVYYRDSRDPVWKGPAKLLWKGEGAVVIQDNSDIKVVPRRKAKIIRDYGKQMAGDDCVASRQDED
  
Inhibitor
Name:
BDBM50480407
Synonyms:
CHEMBL549405
Type:
Small organic molecule
Emp. Form.:
C17H11Cl2NO3
Mol. Mass.:
348.18
SMILES:
OC(=O)c1c[nH]c2ccc(Cc3cc(Cl)ccc3Cl)cc2c1=O
Structure:
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