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Target
Acetylcholinesterase
Ligand
BDBM50064896
Substrate
n/a
Meas. Tech.
ChEMBL_1812363 (CHEMBL4311823)
IC50
>250000±n/a nM
Citation
 Feng, L; Zhang, Y; Liu, YC; Liu, Y; Luo, SH; Huang, CS; Li, SH Leucoflavonine, a new bioactive racemic flavoalkaloid from the leaves of Leucosceptrum canum. Bioorg Med Chem 27:442-446 (2019) [PubMed]  Article 
Target
Name:
Acetylcholinesterase
Synonyms:
ACES_HUMAN | ACHE | Acetylcholinesterase (AChE) | Acetylcholinesterase (human AChE)
Type:
Enzyme
Mol. Mass.:
67792.70
Organism:
Homo sapiens (Human)
Description:
P22303
Residue:
614
Sequence:
MRPPQCLLHTPSLASPLLLLLLWLLGGGVGAEGREDAELLVTVRGGRLRGIRLKTPGGPVSAFLGIPFAEPPMGPRRFLPPEPKQPWSGVVDATTFQSVCYQYVDTLYPGFEGTEMWNPNRELSEDCLYLNVWTPYPRPTSPTPVLVWIYGGGFYSGASSLDVYDGRFLVQAERTVLVSMNYRVGAFGFLALPGSREAPGNVGLLDQRLALQWVQENVAAFGGDPTSVTLFGESAGAASVGMHLLSPPSRGLFHRAVLQSGAPNGPWATVGMGEARRRATQLAHLVGCPPGGTGGNDTELVACLRTRPAQVLVNHEWHVLPQESVFRFSFVPVVDGDFLSDTPEALINAGDFHGLQVLVGVVKDEGSYFLVYGAPGFSKDNESLISRAEFLAGVRVGVPQVSDLAAEAVVLHYTDWLHPEDPARLREALSDVVGDHNVVCPVAQLAGRLAAQGARVYAYVFEHRASTLSWPLWMGVPHGYEIEFIFGIPLDPSRNYTAEEKIFAQRLMRYWANFARTGDPNEPRDPKAPQWPPYTAGAQQYVSLDLRPLEVRRGLRAQACAFWNRFLPKLLSATDTLDEAERQWKAEFHRWSSYMVHWKNQFDHYSKQDRCSDL
  
Inhibitor
Name:
BDBM50064896
Synonyms:
4,5-Dihydroxy-6-methoxy-2-(4-methoxy-phenyl)-chromen-7-one | 5,7-Dihydroxy-6-methoxy-2-(4-methoxy-phenyl)-chromen-4-one | 5,7-dihydroxy-6-methoxy-2-(4-methoxyphenyl)-4H-chromen-4-one | CHEMBL78010 | NSC-106403 | Pectolinarigenin | cid_5320438
Type:
Small organic molecule
Emp. Form.:
C17H14O6
Mol. Mass.:
314.2895
SMILES:
COc1ccc(cc1)-c1cc(=O)c2c(O)c(OC)c(O)cc2o1
Structure:
Search PDB for entries with ligand similarity: