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Target
Mitogen-activated protein kinase 14
Ligand
BDBM50071871
Substrate
n/a
Meas. Tech.
ChEBML_148191
IC50
390±n/a nM
Citation
 de Laszlo, SE; Visco, D; Agarwal, L; Chang, L; Chin, J; Croft, G; Forsyth, A; Fletcher, D; Frantz, B; Hacker, C; Hanlon, W; Harper, C; Kostura, M; Li, B; Luell, S; MacCoss, M; Mantlo, N; O'Neill, EA; Orevillo, C; Pang, M; Parsons, J; Rolando, A; Sahly, Y; Sidler, K; O'Keefe, SJ Pyrroles and other heterocycles as inhibitors of p38 kinase. Bioorg Med Chem Lett 8:2689-94 (1999) [PubMed]  Article 
Target
Name:
Mitogen-activated protein kinase 14
Synonyms:
Csbp1 | Csbp2 | MAP kinase p38 alpha | MK14_RAT | Mapk14
Type:
PROTEIN
Mol. Mass.:
41315.23
Organism:
Rat
Description:
ChEMBL_148191
Residue:
360
Sequence:
MSQERPTFYRQELNKTVWEVPERYQNLSPVGSGAYGSVCAAFDTKTGHRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLAQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHDPDDEPVAEPYDQSFESRDFLIDEWKSLTYDEVISFVPPPLDQEEMES
  
Inhibitor
Name:
BDBM50071871
Synonyms:
CHEMBL91165 | N-[4-(5-Phenyl-4-pyridin-4-yl-1H-pyrrol-2-yl)-phenyl]-3-piperidin-1-yl-propionamide
Type:
Small organic molecule
Emp. Form.:
C29H30N4O
Mol. Mass.:
450.5747
SMILES:
O=C(CCN1CCCCC1)Nc1ccc(cc1)-c1cc(c([nH]1)-c1ccccc1)-c1ccncc1
Structure:
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