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Target
Endothelin receptor type B
Ligand
BDBM50093995
Substrate
n/a
Meas. Tech.
ChEBML_64040
IC50
3.2±n/a nM
Citation
 Zhang, J; Didierlaurent, S; Fortin, M; Lefrançois, D; Uridat, E; Vevert, JP Potent nonpeptide endothelin antagonists: synthesis and structure-activity relationships of pyrazole-5-carboxylic acids. Bioorg Med Chem Lett 10:2575-8 (2001) [PubMed]  Article 
Target
Name:
Endothelin receptor type B
Synonyms:
EDNRB_RAT | ENDOTHELIN B | ET-B | Ednrb | Endothelin receptor | Endothelin receptor non-selective type
Type:
Enzyme Catalytic Domain
Mol. Mass.:
49483.43
Organism:
RAT
Description:
ENDOTHELIN B EDNRB RAT::P21451
Residue:
442
Sequence:
MQSSASRCGRALVALLLACGLLGVWGEKRGFPPAQATPSLLGTKEVMTPPTKTSWTRGSNSSLMRSSAPAEVTKGGRVAGVPPRSFPPPCQRKIEINKTFKYINTIVSCLVFVLGIIGNSTLLRIIYKNKCMRNGPNILIASLALGDLLHIIIDIPINAYKLLAGDWPFGAEMCKLVPFIQKASVGITVLSLCALSIDRYRAVASWSRIKGIGVPKWTAVEIVLIWVVSVVLAVPEAIGFDVITSDYKGKPLRVCMLNPFQKTAFMQFYKTAKDWWLFSFYFCLPLAITAIFYTLMTCEMLRKKSGMQIALNDHLKQRREVAKTVFCLVLVFALCWLPLHLSRILKLTLYDQSNPQRCELLSFLLVLDYIGINMASLNSCINPIALYLVSKRFKNCFKSCLCCWCQTFEEKQSLEEKQSCLKFKANDHGYDNFRSSNKYSSS
  
Inhibitor
Name:
BDBM50093995
Synonyms:
2-(2-Carboxymethoxy-cyclohexylmethyl)-4-(6-chloro-benzo[1,3]dioxol-5-ylmethyl)-5-phenyl-2H-pyrazole-3-carboxylic acid | CHEMBL314973
Type:
Small organic molecule
Emp. Form.:
C27H27ClN2O7
Mol. Mass.:
526.965
SMILES:
OC(=O)COC1CCCCC1Cn1nc(c(Cc2cc3OCOc3cc2Cl)c1C(O)=O)-c1ccccc1
Structure:
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