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Target
Palmitoleoyl-protein carboxylesterase NOTUM
Ligand
BDBM50539227
Substrate
n/a
Meas. Tech.
ChEMBL_1977817 (CHEMBL4610952)
IC50
38±n/a nM
Citation
 Atkinson, BN; Steadman, D; Mahy, W; Zhao, Y; Sipthorp, J; Bayle, ED; Svensson, F; Papageorgiou, G; Jeganathan, F; Frew, S; Monaghan, A; Bictash, M; Jones, EY; Fish, PV Scaffold-hopping identifies furano[2,3-d]pyrimidine amides as potent Notum inhibitors. Bioorg Med Chem Lett 30:0 (2020) [PubMed]  Article 
Target
Name:
Palmitoleoyl-protein carboxylesterase NOTUM
Synonyms:
NOTUM | NOTUM_HUMAN | Palmitoleoyl-protein carboxylesterase NOTUM | hNOTUM
Type:
PROTEIN
Mol. Mass.:
55706.36
Organism:
Homo sapiens (Human)
Description:
ChEMBL_116492
Residue:
496
Sequence:
MGRGVRVLLLLSLLHCAGGSEGRKTWRRRGQQPPPPPRTEAAPAAGQPVESFPLDFTAVEGNMDSFMAQVKSLAQSLYPCSAQQLNEDLRLHLLLNTSVTCNDGSPAGYYLKESRGSRRWLLFLEGGWYCFNRENCDSRYDTMRRLMSSRDWPRTRTGTGILSSQPEENPYWWNANMVFIPYCSSDVWSGASSKSEKNEYAFMGALIIQEVVRELLGRGLSGAKVLLLAGSSAGGTGVLLNVDRVAEQLEKLGYPAIQVRGLADSGWFLDNKQYRHTDCVDTITCAPTEAIRRGIRYWNGVVPERCRRQFQEGEEWNCFFGYKVYPTLRCPVFVVQWLFDEAQLTVDNVHLTGQPVQEGLRLYIQNLGRELRHTLKDVPASFAPACLSHEIIIRSHWTDVQVKGTSLPRALHCWDRSLHDSHKASKTPLKGCPVHLVDSCPWPHCNPSCPTVRDQFTGQEMNVAQFLMHMGFDMQTVAQPQGLEPSELLGMLSNGS
  
Inhibitor
Name:
BDBM50539227
Synonyms:
CHEMBL4639527
Type:
Small organic molecule
Emp. Form.:
C15H12ClF3N6OS2
Mol. Mass.:
448.874
SMILES:
Cc1sc2ncnc(SCC(=O)N3CCn4c(C3)nnc4C(F)(F)F)c2c1Cl
Structure:
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