Reaction Details Report a problem with these data
Target
M-phase inducer phosphatase 2
Ligand
BDBM50104694
Substrate
n/a
Meas. Tech.
ChEMBL_49038 (CHEMBL662076)
IC50
2200±n/a nM
Citation
 Sodeoka, M; Sampe, R; Kojima, S; Baba, Y; Usui, T; Ueda, K; Osada, H Synthesis of a tetronic acid library focused on inhibitors of tyrosine and dual-specificity protein phosphatases and its evaluation regarding VHR and cdc25B inhibition. J Med Chem 44:3216-22 (2001) [PubMed]  Article 
Target
Name:
M-phase inducer phosphatase 2
Synonyms:
Cdc25b | Cdc25m2 | Dual specificity phosphatase Cdc25B | M-phase inducer phosphatase 2 | MPIP2_MOUSE
Type:
PROTEIN
Mol. Mass.:
65485.87
Organism:
Mus musculus
Description:
ChEMBL_49038
Residue:
576
Sequence:
MEVPLQKSAPGSALSPARVLGGIQRPRHLSVFEFESDGFLGSPEPTASSSPVTTLTQTMHNLAGLGSEPPKAQVGSLSFQNRLADLSLSRRTSECSLSSESSESSDAGLCMDSPSPVDPQMAERTFEQAIQAASRVIQNEQFTIKRFRSLPVRLLEHSPVLQSITNSRALDSWRKTEAGYRAAANSPGEDKENDGYIFKMPQELPHSSSAQALAEWVSRRQAFTQRPSSAPDLMCLTTEWKMEVEELSPVAQSSSLTPVERASEEDDGFVDILESDLKDDEKVPAGMENLISAPLVKKLDKEEEQDLIMFSKCQRLFRSPSMPCSVIRPILKRLERPQDRDVPVQSKRRKSVTPLEEQQLEEPKARVFRSKSLCHEIENILDSDHRGLIGDYSKAFLLQTVDGKHQDLKYISPETMVALLTGKFSNIVEKFVIVDCRYPYEYEGGHIKNAVNLPLERDAETFLLQRPIMPCSLDKRIILIFHCEFSSERGPRMCRFIRERDRAANDYPSLYYPEMYILKGGYKEFFPQHPNFCEPQDYRPMNHEAFRDELRNFRLKTRSWAGERSRRELCSRLQDQ
  
Inhibitor
Name:
BDBM50104694
Synonyms:
(R)-4-hydroxy-5-(hydroxymethyl)-3-palmitoylfuran-2(5H)-one | (R)-5-Ethyl-3-hexadecanoyl-4-methyl-5H-furan-2-oneo | 3-Hexadecanoyl-4-hydroxy-5-hydroxymethyl-5H-furan-2-one | CHEMBL108441 | RK-682
Type:
Small organic molecule
Emp. Form.:
C21H36O5
Mol. Mass.:
368.5075
SMILES:
CCCCCCCCCCCCCCCC(=O)c1c(O)oc(CO)c1O
Structure:
Search PDB for entries with ligand similarity: