Reaction Details Report a problem with these data
Target
Type-1 angiotensin II receptor B
Ligand
BDBM50042235
Substrate
n/a
Meas. Tech.
ChEMBL_34836 (CHEMBL648770)
Ki
0.800000±n/a nM
Citation
Murugesan, N; Tellew, JE; Gu, Z; Kunst, BL; Fadnis, L; Cornelius, LA; Baska, RA; Yang, Y; Beyer, SM; Monshizadegan, H; Dickinson, KE; Panchal, B; Valentine, MT; Chong, S; Morrison, RA; Carlson, KE; Powell, JR; Moreland, S; Barrish, JC; Kowala, MC; Macor, JE Discovery of N-isoxazolyl biphenylsulfonamides as potent dual angiotensin II and endothelin A receptor antagonists. J Med Chem 45:3829-35 (2002) [PubMed] Article
More Info.:
Target
Name:
Type-1 angiotensin II receptor B
Synonyms:
AGTRB_RAT | AT3 | Agtr1 | Agtr1b | Angiotensin II AT1B | Angiotensin II receptor (AT-1) type-1 | Angiotensin II type 1b (AT-1b) receptor | At1b | Type-1B angiotensin II receptor
Type:
Enzyme Catalytic Domain
Mol. Mass.:
40929.44
Organism:
Rat
Description:
Angiotensin II AT1B 0 RAT::P29089
Residue:
359
Sequence:
MTLNSSTEDGIKRIQDDCPKAGRHNYIFVMIPTLYSIIFVVGIFGNSLVVIVIYFYMKLKTVASVFLLNLALADLCFLLTLPLWAVYTAMEYRWPFGNHLCKIASASVSFNLYASVFLLTCLSIDRYLAIVHPMKSRLRRTMLVAKVTCIIIWLMAGLASLPAVIYRNVYFIENTNITVCAFHYESQNSTLPIGLGLTKNILGFVFPFLIILTSYTLIWKALKKAYKIQKNTPRNDDIFRIIMAIVLFFFFSWVPHQIFTFLDVLIQLGIIRDCEIADIVDTAMPITICIAYFNNCLNPLFYGFLGKKFKKYFLQLLKYIPPTAKSHAGLSTKMSTLSYRPSDNMSSSAKKSASFFEVE
Inhibitor
Name:
BDBM50042235
Synonyms:
2-butyl-3-{[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl}-1,3-diazaspiro[4.4]non-1-en-4-one | 2-butyl-3-{[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl}-1,3-diazaspiro[4.4]non-1-en-4-one | BMS 186295 | CHEMBL1513 | IRBESARTAN
Type:
Small organic molecule
Emp. Form.:
C25H28N6O
Mol. Mass.:
428.5294
SMILES:
CCCCC1=NC2(CCCC2)C(=O)N1Cc1ccc(cc1)-c1ccccc1-c1nnn[nH]1 |t:4|