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Target
Cathepsin S
Ligand
BDBM50121566
Substrate
n/a
Meas. Tech.
ChEMBL_48674 (CHEMBL658345)
Kd
7±n/a nM
Citation
Ward, YD; Thomson, DS; Frye, LL; Cywin, CL; Morwick, T; Emmanuel, MJ; Zindell, R; McNeil, D; Bekkali, Y; Girardot, M; Hrapchak, M; DeTuri, M; Crane, K; White, D; Pav, S; Wang, Y; Hao, MH; Grygon, CA; Labadia, ME; Freeman, DM; Davidson, W; Hopkins, JL; Brown, ML; Spero, DM; Giradot, M Design and synthesis of dipeptide nitriles as reversible and potent Cathepsin S inhibitors. J Med Chem 45:5471-82 (2002) [PubMed] Article
More Info.:
Target
Name:
Cathepsin S
Synonyms:
CATS_HUMAN | CTSS | Cathepsin S (Cat S) | cathepsin S preproprotein
Type:
Protein
Mol. Mass.:
37507.38
Organism:
Human
Description:
P25774
Residue:
331
Sequence:
MKRLVCVLLVCSSAVAQLHKDPTLDHHWHLWKKTYGKQYKEKNEEAVRRLIWEKNLKFVMLHNLEHSMGMHSYDLGMNHLGDMTSEEVMSLMSSLRVPSQWQRNITYKSNPNRILPDSVDWREKGCVTEVKYQGSCGACWAFSAVGALEAQLKLKTGKLVSLSAQNLVDCSTEKYGNKGCNGGFMTTAFQYIIDNKGIDSDASYPYKAMDQKCQYDSKYRAATCSKYTELPYGREDVLKEAVANKGPVSVGVDARHPSFFLYRSGVYYEPSCTQNVNHGVLVVGYGDLNGKEYWLVKNSWGHNFGEEGYIRMARNKGNHCGIASFPSYPEI
Inhibitor
Name:
BDBM50121566
Synonyms:
CHEMBL153319 | Morpholine-4-carboxylic acid (1-{[cyano-(3,4-dichloro-benzyl)-methyl]-carbamoyl}-3-methyl-butyl)-amide
Type:
Small organic molecule
Emp. Form.:
C20H26Cl2N4O3
Mol. Mass.:
441.351
SMILES:
CC(C)C[C@H](NC(=O)N1CCOCC1)C(=O)N[C@@H](Cc1ccc(Cl)c(Cl)c1)C#N