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Target
Calpain-1 catalytic subunit
Ligand
BDBM50149195
Substrate
n/a
Meas. Tech.
ChEMBL_43656 (CHEMBL654082)
IC50
20±n/a nM
Citation
 Auvin, S; Pignol, B; Navet, E; Pons, D; Marin, JG; Bigg, D; Chabrier, PE Novel dual inhibitors of calpain and lipid peroxidation. Bioorg Med Chem Lett 14:3825-8 (2004) [PubMed]  Article 
Target
Name:
Calpain-1 catalytic subunit
Synonyms:
CAN1_HUMAN | CANPL1 | CAPN1 | Calpain ยต-type | Calpain-1 (u-Calpain) | Calpain-1 catalytic subunit | Calpain1
Type:
Protein
Mol. Mass.:
81880.51
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
714
Sequence:
MSEEIITPVYCTGVSAQVQKQRARELGLGRHENAIKYLGQDYEQLRVRCLQSGTLFRDEAFPPVPQSLGYKDLGPNSSKTYGIKWKRPTELLSNPQFIVDGATRTDICQGALGDCWLLAAIASLTLNDTLLHRVVPHGQSFQNGYAGIFHFQLWQFGEWVDVVVDDLLPIKDGKLVFVHSAEGNEFWSALLEKAYAKVNGSYEALSGGSTSEGFEDFTGGVTEWYELRKAPSDLYQIILKALERGSLLGCSIDISSVLDMEAITFKKLVKGHAYSVTGAKQVNYRGQVVSLIRMRNPWGEVEWTGAWSDSSSEWNNVDPYERDQLRVKMEDGEFWMSFRDFMREFTRLEICNLTPDALKSRTIRKWNTTLYEGTWRRGSTAGGCRNYPATFWVNPQFKIRLDETDDPDDYGDRESGCSFVLALMQKHRRRERRFGRDMETIGFAVYEVPPELVGQPAVHLKRDFFLANASRARSEQFINLREVSTRFRLPPGEYVVVPSTFEPNKEGDFVLRFFSEKSAGTVELDDQIQANLPDEQVLSEEEIDENFKALFRQLAGEDMEISVKELRTILNRIISKHKDLRTKGFSLESCRSMVNLMDRDGNGKLGLVEFNILWNRIRNYLSIFRKFDLDKSGSMSAYEMRMAIESAGFKLNKKLYELIITRYSEPDLAVDFDNFVCCLVRLETMFRFFKTLDTDLDGVVTFDLFKWLQLTMFA
  
Inhibitor
Name:
BDBM50149195
Synonyms:
1-Benzyl-2,3-dihydro-1H-indole-5-carboxylic acid [(S)-1-((S)-2-hydroxy-tetrahydro-furan-3-ylcarbamoyl)-3-methyl-butyl]-amide | CHEMBL333995
Type:
Small organic molecule
Emp. Form.:
C26H33N3O4
Mol. Mass.:
451.5579
SMILES:
CC(C)C[C@H](NC(=O)c1ccc2N(Cc3ccccc3)CCc2c1)C(=O)N[C@H]1CCOC1O
Structure:
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