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Target
Paired box protein Pax-3
Ligand
BDBM50595106
Substrate
n/a
Meas. Tech.
ChEMBL_2215519 (CHEMBL5128651)
IC50
42000±n/a nM
Citation
 Jiang, W; Tian, X; Wang, D; Bokesch, HR; Thomas, CL; Woldemichael, GM; Gryder, BE; Wei, JS; Song, YK; Chou, HC; Khan, J; O'Keefe, BR; Gustafson, KR Dentithecamides A-H, Diacylated Zoanthoxanthin Derivatives with PAX3-FOXO1 Inhibitory Activity from the Hydroid  J Nat Prod 85:1419-1427 (2022) [PubMed] 
Target
Name:
Paired box protein Pax-3
Synonyms:
HUP2 | PAX3 | PAX3_HUMAN
Type:
PROTEIN
Mol. Mass.:
52981.03
Organism:
Homo sapiens
Description:
ChEMBL_120792
Residue:
479
Sequence:
MTTLAGAVPRMMRPGPGQNYPRSGFPLEVSTPLGQGRVNQLGGVFINGRPLPNHIRHKIVEMAHHGIRPCVISRQLRVSHGCVSKILCRYQETGSIRPGAIGGSKPKQVTTPDVEKKIEEYKRENPGMFSWEIRDKLLKDAVCDRNTVPSVSSISRILRSKFGKGEEEEADLERKEAEESEKKAKHSIDGILSERASAPQSDEGSDIDSEPDLPLKRKQRRSRTTFTAEQLEELERAFERTHYPDIYTREELAQRAKLTEARVQVWFSNRRARWRKQAGANQLMAFNHLIPGGFPPTAMPTLPTYQLSETSYQPTSIPQAVSDPSSTVHRPQPLPPSTVHQSTIPSNPDSSSAYCLPSTRHGFSSYTDSFVPPSGPSNPMNPTIGNGLSPQVMGLLTNHGGVPHQPQTDYALSPLTGGLEPTTTVSASCSQRLDHMKSLDSLPTSQSYCPPTYSTTGYSMDPVTGYQYGQYGQSKPWTF
  
Inhibitor
Name:
BDBM50595106
Synonyms:
CHEMBL5180582
Type:
Small organic molecule
Emp. Form.:
C24H28N6O2
Mol. Mass.:
432.5181
SMILES:
CC[C@H](C)C(=O)Nc1nc2CCc3nc(NC(=O)\C=C\c4ccccc4)[nH]c3C(C)c2[nH]1 |r|
Structure:
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